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Literature summary extracted from

  • Breault, G.A.; Comita-Prevoir, J.; Eyermann, C.J.; Geng, B.; Petrichko, R.; Doig, P.; Gorseth, E.; Noonan, B.
    Exploring 8-benzyl pteridine-6,7-diones as inhibitors of glutamate racemase (MurI) in gram-positive bacteria (2008), Bioorg. Med. Chem. Lett., 18, 6100-6103.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.1.1.3 2-(butylsulfanyl)-8-(4-fluorobenzyl)-4-(methylamino)-5,8-dihydropteridine-6,7-dione comparison with effect on enzyme from Staphylococcus aureus Enterococcus faecalis
5.1.1.3 2-(butylsulfanyl)-8-(4-fluorobenzyl)-4-(methylamino)-5,8-dihydropteridine-6,7-dione comparison with effect on enzyme from Enterococcus faecalis Staphylococcus aureus
5.1.1.3 2-(butylsulfanyl)-9-(4-nitrophenyl)-9H-purin-6-amine comparison with effect on enzyme from Staphylococcus aureus Enterococcus faecalis
5.1.1.3 2-(butylsulfanyl)-9-(4-nitrophenyl)-9H-purin-6-amine comparison with effect on enzyme from Enterococcus faecalis and Staphylococcus aureus Enterococcus faecium
5.1.1.3 2-(butylsulfanyl)-9-(4-nitrophenyl)-9H-purin-6-amine comparison with effect on enzyme from Enterococcus faecalis Staphylococcus aureus
5.1.1.3 4-amino-2-(butylsulfanyl)-8-(2,6-difluorobenzyl)-5,8-dihydropteridine-6,7-dione comparison with effect on enzyme from Staphylococcus aureus Enterococcus faecalis
5.1.1.3 4-amino-2-(butylsulfanyl)-8-(2,6-difluorobenzyl)-5,8-dihydropteridine-6,7-dione comparison with effect on enzyme from Enterococcus faecalis Staphylococcus aureus
5.1.1.3 4-amino-2-(butylsulfanyl)-8-(3,4-dichlorobenzyl)-5,8-dihydropteridine-6,7-dione comparison with effect on enzyme from Staphylococcus aureus Enterococcus faecalis
5.1.1.3 4-amino-2-(butylsulfanyl)-8-(3,4-dichlorobenzyl)-5,8-dihydropteridine-6,7-dione comparison with effect on enzyme from Enterococcus faecalis Staphylococcus aureus
5.1.1.3 4-amino-2-(butylsulfanyl)-8-(4-fluorobenzyl)-5,8-dihydropteridine-6,7-dione comparison with effect on enzyme from Staphylococcus aureus Enterococcus faecalis
5.1.1.3 4-amino-2-(butylsulfanyl)-8-(4-fluorobenzyl)-5,8-dihydropteridine-6,7-dione comparison with effect on enzyme from Enterococcus faecalis Staphylococcus aureus
5.1.1.3 4-amino-8-benzyl-2-(benzylsulfanyl)-5,8-dihydropteridine-6,7-dione comparison with effect on enzyme from Staphylococcus aureus Enterococcus faecalis
5.1.1.3 4-amino-8-benzyl-2-(benzylsulfanyl)-5,8-dihydropteridine-6,7-dione comparison with effect on enzyme from Enterococcus faecalis Staphylococcus aureus
5.1.1.3 4-amino-8-benzyl-2-(butylsulfanyl)-5,8-dihydropteridine-6,7-dione comparison with effect on enzyme from Staphylococcus aureus Enterococcus faecalis
5.1.1.3 4-amino-8-benzyl-2-(butylsulfanyl)-5,8-dihydropteridine-6,7-dione comparison with effect on enzyme from Enterococcus faecalis Staphylococcus aureus
5.1.1.3 4-amino-8-benzyl-2-(cyclopentylsulfanyl)-5,8-dihydropteridine-6,7-dione comparison with effect on enzyme from Staphylococcus aureus Enterococcus faecalis
5.1.1.3 4-amino-8-benzyl-2-(cyclopentylsulfanyl)-5,8-dihydropteridine-6,7-dione comparison with effect on enzyme from Enterococcus faecalis Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
5.1.1.3 Enterococcus faecalis
-
-
-
5.1.1.3 Enterococcus faecium
-
-
-
5.1.1.3 Staphylococcus aureus
-
-
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.1.1.3 0.00065
-
-
 Enterococcus faecalis 4-amino-2-(butylsulfanyl)-8-(3,4-dichlorobenzyl)-5,8-dihydropteridine-6,7-dione
5.1.1.3 0.0009
-
-
 Enterococcus faecalis 2-(butylsulfanyl)-8-(4-fluorobenzyl)-4-(methylamino)-5,8-dihydropteridine-6,7-dione
5.1.1.3 0.0011
-
-
 Staphylococcus aureus 4-amino-2-(butylsulfanyl)-8-(4-fluorobenzyl)-5,8-dihydropteridine-6,7-dione
5.1.1.3 0.0015
-
-
 Enterococcus faecalis 4-amino-2-(butylsulfanyl)-8-(2,6-difluorobenzyl)-5,8-dihydropteridine-6,7-dione
5.1.1.3 0.0015
-
-
 Staphylococcus aureus 4-amino-2-(butylsulfanyl)-8-(3,4-dichlorobenzyl)-5,8-dihydropteridine-6,7-dione
5.1.1.3 0.0019
-
-
 Enterococcus faecalis 4-amino-8-benzyl-2-(cyclopentylsulfanyl)-5,8-dihydropteridine-6,7-dione
5.1.1.3 0.0024
-
-
 Enterococcus faecalis 4-amino-8-benzyl-2-(butylsulfanyl)-5,8-dihydropteridine-6,7-dione
5.1.1.3 0.0031
-
-
 Staphylococcus aureus 4-amino-2-(butylsulfanyl)-8-(2,6-difluorobenzyl)-5,8-dihydropteridine-6,7-dione
5.1.1.3 0.0035
-
-
 Enterococcus faecalis 4-amino-2-(butylsulfanyl)-8-(4-fluorobenzyl)-5,8-dihydropteridine-6,7-dione
5.1.1.3 0.0038
-
-
 Staphylococcus aureus 2-(butylsulfanyl)-8-(4-fluorobenzyl)-4-(methylamino)-5,8-dihydropteridine-6,7-dione
5.1.1.3 0.0064
-
-
 Staphylococcus aureus 4-amino-8-benzyl-2-(butylsulfanyl)-5,8-dihydropteridine-6,7-dione
5.1.1.3 0.007
-
-
 Enterococcus faecalis 2-(butylsulfanyl)-9-(4-nitrophenyl)-9H-purin-6-amine
5.1.1.3 0.0076
-
-
 Staphylococcus aureus 4-amino-8-benzyl-2-(benzylsulfanyl)-5,8-dihydropteridine-6,7-dione
5.1.1.3 0.018
-
-
 Enterococcus faecium 2-(butylsulfanyl)-9-(4-nitrophenyl)-9H-purin-6-amine
5.1.1.3 0.021
-
-
 Enterococcus faecalis 4-amino-8-benzyl-2-(benzylsulfanyl)-5,8-dihydropteridine-6,7-dione
5.1.1.3 0.052
-
-
 Staphylococcus aureus 4-amino-8-benzyl-2-(cyclopentylsulfanyl)-5,8-dihydropteridine-6,7-dione
5.1.1.3 0.4
-
-
 Staphylococcus aureus 2-(butylsulfanyl)-9-(4-nitrophenyl)-9H-purin-6-amine