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Literature summary extracted from

  • Bhattacharya, S.; Labutti, J.N.; Seiner, D.R.; Gates, K.S.
    Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides (2008), Bioorg. Med. Chem. Lett., 18, 5856-5859.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.48 2-carboperoxybenzoate complete inhibition at 150 mM Homo sapiens
3.1.3.48 2-hydroperoxytetrahydrofuran inactivation by 2-hydroperoxytetrahydrofuran (0.05 mM, 10 min) is reversed upon reaction of the enzyme with dithiothreitol (54% return of activity, following treatment with 100 mM dthiothreitol for 1 h) Homo sapiens
3.1.3.48 3-chlorobenzenecarboperoxoic acid complete inhibition at 150 mM Homo sapiens
3.1.3.48 additional information tert-butyl hydroperoxide cumene hydroperoxide do not inactivate PTP1B, 150 nM H2O2 has no measurable effect on enzyme activity Homo sapiens
3.1.3.48 peracetic acid a potent, time-dependent inactivator of the catalytic subunit of PTP1B, treatment of the enzyme with 0.015 mM for 15 sec inactivates 88% of the enzyme, inactivation of PTP1B by peracetic acid can be reversed by treatment of the enzyme with thiols Homo sapiens
3.1.3.48 PO43- treatment of the enzyme with 0.05 mM PO43- for 15 sec inactivates 49% of the enzyme Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 phosphotyrosine + H2O
-
 Homo sapiens tyrosine + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 protein tyrosine phosphatase 1B
-
 Homo sapiens
3.1.3.48 PTP1B
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.3.48 0.017
-
 PO43- active site-directed inhibitor Homo sapiens