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Literature summary extracted from

  • Pan, L.; Tan, J.H.; Hou, J.Q.; Huang, S.L.; Gu, L.Q.; Huang, Z.S.
    Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors (2008), Bioorg. Med. Chem. Lett., 18, 3790-3793.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 (3E)-3-([4-[2-(diethylamino)ethoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Electrophorus electricus
3.1.1.7 (3E)-3-([4-[3-(diethylamino)propoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Electrophorus electricus
3.1.1.7 (3E)-3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Electrophorus electricus
3.1.1.7 (3E)-3-[(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Electrophorus electricus
3.1.1.7 (3E)-3-[(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Electrophorus electricus
3.1.1.7 2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Electrophorus electricus
3.1.1.7 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
-
Electrophorus electricus
3.1.1.7 3-(4-propoxybenzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Electrophorus electricus
3.1.1.7 3-(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Electrophorus electricus
3.1.1.7 3-(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Electrophorus electricus
3.1.1.7 3-[4-[3-(diethylamino)propoxy]benzyl]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Electrophorus electricus
3.1.1.7 additional information selectivity and inhibitory potency of isaindigotone derivatives for inhibition of AChE Electrophorus electricus
3.1.1.7 tacrine
-
Electrophorus electricus
3.1.1.8 (3E)-3-([4-[2-(diethylamino)ethoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Equus caballus
3.1.1.8 (3E)-3-([4-[3-(diethylamino)propoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Equus caballus
3.1.1.8 (3E)-3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Equus caballus
3.1.1.8 (3E)-3-[(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Equus caballus
3.1.1.8 (3E)-3-[(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Equus caballus
3.1.1.8 2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Equus caballus
3.1.1.8 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
-
Equus caballus
3.1.1.8 3-(4-propoxybenzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Equus caballus
3.1.1.8 3-(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Equus caballus
3.1.1.8 3-(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Equus caballus
3.1.1.8 3-[4-[3-(diethylamino)propoxy]benzyl]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
Equus caballus
3.1.1.8 additional information selectivity and inhibitory potency of isaindigotone derivatives for inhibition of BuChE Equus caballus
3.1.1.8 tacrine
-
Equus caballus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Electrophorus electricus
-
-
-
3.1.1.8 Equus caballus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.8 serum
-
Equus caballus
-

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
Electrophorus electricus
3.1.1.8 BuChE
-
Equus caballus
3.1.1.8 butyrylcholinesterase
-
Equus caballus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.7 0.1
-
-
Electrophorus electricus tacrine
3.1.1.7 0.16
-
-
Electrophorus electricus (3E)-3-[(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
3.1.1.7 0.48
-
-
Electrophorus electricus (3E)-3-([4-[2-(diethylamino)ethoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
3.1.1.7 0.72
-
-
Electrophorus electricus (3E)-3-[(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
3.1.1.7 0.75
-
-
Electrophorus electricus 3-(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
3.1.1.7 1.62
-
-
Electrophorus electricus 3-(4-propoxybenzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
3.1.1.7 2.41
-
-
Electrophorus electricus (3E)-3-([4-[3-(diethylamino)propoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
3.1.1.7 5.58
-
-
Electrophorus electricus 3-(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
3.1.1.7 8.95
-
-
Electrophorus electricus 3-[4-[3-(diethylamino)propoxy]benzyl]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
3.1.1.8 0.00001
-
-
Equus caballus tacrine
3.1.1.8 0.0017
-
-
Equus caballus (3E)-3-[(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
3.1.1.8 0.003
-
-
Equus caballus (3E)-3-[(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
3.1.1.8 0.0057
-
-
Equus caballus 3-(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
3.1.1.8 0.0071
-
-
Equus caballus (3E)-3-([4-[3-(diethylamino)propoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
3.1.1.8 0.0083
-
-
Equus caballus 3-(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
3.1.1.8 0.0127
-
-
Equus caballus (3E)-3-([4-[2-(diethylamino)ethoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
3.1.1.8 0.02
-
above Equus caballus 3-(4-propoxybenzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
3.1.1.8 0.02
-
above Equus caballus 3-[4-[3-(diethylamino)propoxy]benzyl]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one