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Literature summary extracted from

  • Berkov, S.; Codina, C.; Viladomat, F.; Bastida, J.
    N-Alkylated galanthamine derivatives: potent acetylcholinesterase inhibitors from Leucojum aestivum (2008), Bioorg. Med. Chem. Lett., 18, 2263-2266.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 epinorgalanthamine isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves Tetronarce californica
3.1.1.7 galanthamine isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves Tetronarce californica
3.1.1.7 lycorine isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves Tetronarce californica
3.1.1.7 additional information inhibitor structural screening by GC-MS, binding structure, overview Tetronarce californica
3.1.1.7 N-(14-methylallyl)norgalanthamine isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves, structure determination by NMR spectroscopy Tetronarce californica
3.1.1.7 N-allylnorgalanthamine isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves, structure determination by NMR spectroscopy Tetronarce californica
3.1.1.7 narwedine isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves Tetronarce californica

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Tetronarce californica
-
-
-

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
 Tetronarce californica

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.7 0.00016
-
-
 Tetronarce californica N-(14-methylallyl)norgalanthamine
3.1.1.7 0.00018
-
-
 Tetronarce californica N-allylnorgalanthamine
3.1.1.7 0.00182
-
-
 Tetronarce californica galanthamine