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Literature summary extracted from

  • Triola, G.; Wetzel, S.; Ellinger, B.; Koch, M.; Huebel, K.; Rauh, D.; Waldmann, H.
    ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds (2008), Bioorg. Med. Chem., 17, 1079-1087.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.3.2.4 A771726 a leflunomide metabolite, slightly activating Escherichia coli
6.3.2.4 N-(2,5-dibromophenyl)-2-oxopropanamide slightly activating Escherichia coli

Application

EC Number Application Comment Organism
6.3.2.4 drug development the enzyme is a target for antibiotic inhibitor development, overview Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.4 (2Z)-N-(2-chloro-6-methylphenyl)-2-ethynyl-3-hydroxybut-2-enamide
-
 Escherichia coli
6.3.2.4 D-cycloserine competitive inhibitor Escherichia coli
6.3.2.4 diazenocarboxamide
-
 Escherichia coli
6.3.2.4 H-1004 slight inhibition Escherichia coli
6.3.2.4 leflunomide an antirheumatic drug Escherichia coli
6.3.2.4 LFM-A12 an analog of the Leflunomide metabolite A771726 Escherichia coli
6.3.2.4 LFM-A13 Brutons's tyrosine kinase inhibitor, an analog of the Leflunomide metabolite A771726 Escherichia coli
6.3.2.4 LY294002 slight inhibition Escherichia coli
6.3.2.4 additional information antibiotic inhibitor design, bisubstrate inhibitors that block the ATP and D-Ala binding sites exhibit enhanced selectivity and potency profiles by preferentially inhibiting DDl over kinases, overview Escherichia coli
6.3.2.4 N-(2,5-dibromophenyl)-2-oxopropanamide
-
 Escherichia coli
6.3.2.4 Olomoucine
-
 Escherichia coli
6.3.2.4 piceatannol slight inhibition Escherichia coli
6.3.2.4 quercetin
-
 Escherichia coli
6.3.2.4 tyrphostin 47 competitive versus ATP Escherichia coli
6.3.2.4 tyrphostin 51 mixed-type inhibition Escherichia coli
6.3.2.4 Wortmannin slight inhibition Escherichia coli
6.3.2.4 [3-chloro-2,2-dimethyl-N-4(trimethylfluoro)phenyl]propanamide
-
 Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.4 Mg2+
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.4 ATP + D-alanine Escherichia coli
-
 ADP + phosphate + D-alanyl-D-alanine
-
 ?
6.3.2.4 additional information Escherichia coli DDl is an essential enzyme in bacterial cell wall biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.4 Escherichia coli P07862 two isoforms of DDl, DDlA and DDlB
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.4 ATP + D-alanine
-
 Escherichia coli ADP + phosphate + D-alanyl-D-alanine
-
 ?
6.3.2.4 additional information DDl is an essential enzyme in bacterial cell wall biosynthesis Escherichia coli ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.4 DD1
-
 Escherichia coli
6.3.2.4 DDI
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.2.4 ATP
-
 Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.3.2.4 0.185
-
 D-cycloserine
-
 Escherichia coli
6.3.2.4 0.185
-
 LFM-A13
-
 Escherichia coli
6.3.2.4 0.215
-
 N-(2,5-dibromophenyl)-2-oxopropanamide
-
 Escherichia coli
6.3.2.4 0.29
-
 tyrphostin 47
-
 Escherichia coli
6.3.2.4 1.4
-
 LY294002
-
 Escherichia coli
6.3.2.4 1.8
-
 Olomoucine
-
 Escherichia coli