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Literature summary extracted from

  • Zhang, Y.N.; Zhang, W.; Hong, D.; Shi, L.; Shen, Q.; Li, J.Y.; Li, J.; Hu, L.H.
    Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities (2008), Bioorg. Med. Chem., 16, 8697-8705.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.48 expressed in CHO cells and L6 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.48 28-(10-decanoic)-oleanolic acid
-
 Homo sapiens
3.1.3.48 28-(12-dodecanoic)-oleanolic acid
-
 Homo sapiens
3.1.3.48 28-(2-acetic)-oleanolic acid
-
 Homo sapiens
3.1.3.48 28-(4-butyric)-oleanolic acid
-
 Homo sapiens
3.1.3.48 28-(6-hexanoic)-oleanolic acid
-
 Homo sapiens
3.1.3.48 28-(8-octanoic)-oleanolic acid
-
 Homo sapiens
3.1.3.48 28-(glycine)-oleanolic acid amide
-
 Homo sapiens
3.1.3.48 28-(L-glutamic acid)-oleanolic acid amide
-
 Homo sapiens
3.1.3.48 28-(L-phenylalanine)-oleanolic acid amide
-
 Homo sapiens
3.1.3.48 28-(p-carboxyphenyl)-oleanolic acid amide
-
 Homo sapiens
3.1.3.48 28-[4-butyric((R)-1-carboxy-phenylethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 28-[4-butyric((S)-1-carboxy-3-indole-ethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 28-[4-butyric((S)-1-carboxy-5-imidazole-ethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 28-[4-butyric((S)-1-carboxy-methylthioethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 28-[4-butyric((S)-1-carboxy-phenylethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 28-[4-butyric(1-carboxy-2,3-dimethoxyphenylethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 28-[4-butyric(1-carboxy-3,4-dimethoxyphenylethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 28-[4-butyric(1-carboxy-3,4-oxymethyleneoxyphenylethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 28-[4-butyric(1-carboxy-3,5-dimethoxyphenylethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 28-[4-butyric(1-carboxy-m-chlorophenylethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 28-[4-butyric(1-carboxy-m-methoxyphenylethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 28-[4-butyric(1-carboxy-o-chlorophenylethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 28-[4-butyric(1-carboxy-o-methoxyphenylethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 28-[4-butyric(1-carboxy-o-methylphenylethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 28-[4-butyric(1-carboxy-p-chlorophenylethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 28-[4-butyric(1-carboxy-p-fluorophenylethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 28-[4-butyric(1-carboxy-p-methoxyphenylethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 28-[4-butyric(1-carboxy-p-methylphenylethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 28-[4-butyric(1-carboxy-p-nitrophenylethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 3-(2,2'-dimethyl-carboxypropanoyloxy)-oleanolic acid
-
 Homo sapiens
3.1.3.48 3-(2-carboxy-benzyloxy)-oleanolic acid
-
 Homo sapiens
3.1.3.48 3-(2-carboxybenzoyloxy)-oleanolic acid
-
 Homo sapiens
3.1.3.48 3-(3-carboxy-benzyloxy)-oleanolic acid
-
 Homo sapiens
3.1.3.48 3-(4-carboxy-benzyloxy)-28-[4-butyric((s)-1-carboxyphenylethyl)-amide]-DELTA12-oleanene
-
 Homo sapiens
3.1.3.48 3-(4-carboxy-benzyloxy)-oleanolic acid
-
 Homo sapiens
3.1.3.48 3-benzyloxy-oleanolic acid
-
 Homo sapiens
3.1.3.48 3-carboxypropanoyloxy-oleanolic acid
-
 Homo sapiens
3.1.3.48 3-dehydroxy-oleanolic acid
-
 Homo sapiens
3.1.3.48 3-ethyl oxalyl-oleanolic acid
-
 Homo sapiens
3.1.3.48 3-methylene-oleanolic acid
-
 Homo sapiens
3.1.3.48 3-oxalyl-oleanolic acid
-
 Homo sapiens
3.1.3.48 3-oxo-oleanolic acid
-
 Homo sapiens
3.1.3.48 3alpha-oleanolic acid
-
 Homo sapiens
3.1.3.48 4,4'-[benzene-1,4-diylbis(methanediyloxy)]dibenzoic acid
-
 Homo sapiens
3.1.3.48 benzyl oleanolic acid amide
-
 Homo sapiens
3.1.3.48 benzyl oleanolic acid ester
-
 Homo sapiens
3.1.3.48 methyl oleanolic acid amide
-
 Homo sapiens
3.1.3.48 methyl oleanolic acid ester
-
 Homo sapiens
3.1.3.48 oleanolic acid
-
 Homo sapiens
3.1.3.48 oleanolic acid amide
-
 Homo sapiens
3.1.3.48 oleanolic alcohol
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Homo sapiens P29350
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.48 phosphorylated insulin receptor + H2O
-
 Homo sapiens insulin receptor + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 protein tyrosine phosphatase 1B
-
 Homo sapiens
3.1.3.48 PTP1B
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.3.48 0.00015
-
-
 Homo sapiens 3-(4-carboxy-benzyloxy)-28-[4-butyric((s)-1-carboxyphenylethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00044
-
-
 Homo sapiens 28-[4-butyric(1-carboxy-3,4-oxymethyleneoxyphenylethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00045
-
-
 Homo sapiens 28-[4-butyric(1-carboxy-p-nitrophenylethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00051
-
-
 Homo sapiens 28-[4-butyric(1-carboxy-m-chlorophenylethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00052
-
-
 Homo sapiens 28-[4-butyric(1-carboxy-m-methoxyphenylethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00053
-
-
 Homo sapiens 28-[4-butyric(1-carboxy-o-methoxyphenylethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00054
-
-
 Homo sapiens 3-(4-carboxy-benzyloxy)-oleanolic acid
3.1.3.48 0.00055
-
-
 Homo sapiens 28-[4-butyric((S)-1-carboxy-methylthioethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00055
-
-
 Homo sapiens 28-[4-butyric(1-carboxy-o-methylphenylethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00056
-
-
 Homo sapiens 28-[4-butyric(1-carboxy-o-chlorophenylethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00057
-
-
 Homo sapiens 28-[4-butyric((S)-1-carboxy-phenylethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00057
-
-
 Homo sapiens 28-[4-butyric(1-carboxy-p-fluorophenylethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00059
-
-
 Homo sapiens 28-(12-dodecanoic)-oleanolic acid
3.1.3.48 0.00059
-
-
 Homo sapiens 28-[4-butyric((S)-1-carboxy-3-indole-ethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.0006
-
-
 Homo sapiens 28-[4-butyric(1-carboxy-p-methoxyphenylethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00061
-
-
 Homo sapiens 28-[4-butyric(1-carboxy-p-chlorophenylethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00062
-
-
 Homo sapiens 3-(3-carboxy-benzyloxy)-oleanolic acid
3.1.3.48 0.00063
-
-
 Homo sapiens 28-[4-butyric(1-carboxy-3,5-dimethoxyphenylethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00065
-
-
 Homo sapiens 28-[4-butyric(1-carboxy-p-methylphenylethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00066
-
-
 Homo sapiens 28-[4-butyric(1-carboxy-2,3-dimethoxyphenylethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00072
-
-
 Homo sapiens 28-(10-decanoic)-oleanolic acid
3.1.3.48 0.00074
-
-
 Homo sapiens 28-[4-butyric((R)-1-carboxy-phenylethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00078
-
-
 Homo sapiens 28-(8-octanoic)-oleanolic acid
3.1.3.48 0.00082
-
-
 Homo sapiens 28-[4-butyric(1-carboxy-3,4-dimethoxyphenylethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00088
-
-
 Homo sapiens 28-(6-hexanoic)-oleanolic acid
3.1.3.48 0.00133
-
-
 Homo sapiens 28-(4-butyric)-oleanolic acid
3.1.3.48 0.0021
-
-
 Homo sapiens 28-(2-acetic)-oleanolic acid
3.1.3.48 0.00233
-
-
 Homo sapiens 3-(2,2'-dimethyl-carboxypropanoyloxy)-oleanolic acid
3.1.3.48 0.00261
-
-
 Homo sapiens 3-dehydroxy-oleanolic acid
3.1.3.48 0.00267
-
-
 Homo sapiens 3-benzyloxy-oleanolic acid
3.1.3.48 0.00272
-
-
 Homo sapiens 3-(2-carboxy-benzyloxy)-oleanolic acid
3.1.3.48 0.00285
-
-
 Homo sapiens 3-methylene-oleanolic acid
3.1.3.48 0.00286
-
-
 Homo sapiens 3-oxalyl-oleanolic acid
3.1.3.48 0.00289
-
-
 Homo sapiens 3-ethyl oxalyl-oleanolic acid
3.1.3.48 0.00319
-
-
 Homo sapiens 28-(p-carboxyphenyl)-oleanolic acid amide
3.1.3.48 0.00331
-
-
 Homo sapiens 28-(L-phenylalanine)-oleanolic acid amide
3.1.3.48 0.0037
-
-
 Homo sapiens oleanolic acid
3.1.3.48 0.00444
-
-
 Homo sapiens methyl oleanolic acid ester
3.1.3.48 0.00458
-
-
 Homo sapiens 3-(2-carboxybenzoyloxy)-oleanolic acid
3.1.3.48 0.00462
-
-
 Homo sapiens 28-[4-butyric((S)-1-carboxy-5-imidazole-ethyl)-amide]-DELTA12-oleanene
3.1.3.48 0.00476
-
-
 Homo sapiens oleanolic acid amide
3.1.3.48 0.00505
-
-
 Homo sapiens 3alpha-oleanolic acid
3.1.3.48 0.00532
-
-
 Homo sapiens 3-oxo-oleanolic acid
3.1.3.48 0.00573
-
-
 Homo sapiens 4,4'-[benzene-1,4-diylbis(methanediyloxy)]dibenzoic acid
3.1.3.48 0.00597
-
-
 Homo sapiens 3-carboxypropanoyloxy-oleanolic acid
3.1.3.48 0.0081
-
-
 Homo sapiens benzyl oleanolic acid amide
3.1.3.48 0.00861
-
-
 Homo sapiens benzyl oleanolic acid ester
3.1.3.48 0.0092
-
-
 Homo sapiens methyl oleanolic acid amide
3.1.3.48 0.01544
-
-
 Homo sapiens 28-(glycine)-oleanolic acid amide
3.1.3.48 0.01635
-
-
 Homo sapiens 28-(L-glutamic acid)-oleanolic acid amide
3.1.3.48 0.02
-
 IC50 above 0.02 mM Homo sapiens oleanolic alcohol