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Literature summary extracted from
- Characterization of the PON1 active site using modeling simulation, in relation to PON1 lactonase activity (2008), Bioorg. Med. Chem., 16, 7504-7509.
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.2 | Ca2+ | dependent on | Homo sapiens |  |
| 3.1.1.25 | Ca2+ | dependent on | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.2 | Homo sapiens | P27169 | - |
- |
| 3.1.1.17 | Homo sapiens | - |
- |
- |
| 3.1.1.25 | Homo sapiens | P27169 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.2 | blood plasma | - |
Homo sapiens | - |
| 3.1.1.25 | blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.2 | additional information | PON1 hydrolyzes organophosphates, arylesters and lactones, whereas the lactones activity is assumed as the physio/pathological one | Homo sapiens | ? | - |
? | |
| 3.1.1.2 | phenyl acetate + H2O | shows highest hydrolytic rate towards phenyl acetate | Homo sapiens | phenol + acetate | - |
? | |
| 3.1.1.17 | (1R,5S)-oxabicyclooctenone + H2O | hydrolysis: 0.83 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | (1S,5R)-oxabicyclooctenone + H2O | hydrolysis: 1.67 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | alpha-angelica lactone + H2O | hydrolysis: 18.3 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | beta-hydroxybutyrolactone + H2O | hydrolysis: 3.83 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | delta-decanolactone + H2O | hydrolysis: 25.1 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | delta-dodecanolactone + H2O | hydrolysis: 9.65 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | delta-hexalactone + H2O | hydrolysis: 7.2 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | delta-nonalactone + H2O | hydrolysis: 15 micromol/min/mg | Homo sapiens | 5-hydroxynonanoate | - |
? | |
| 3.1.1.17 | delta-undecatiolactone + H2O | hydrolysis: 28.7 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | delta-valerolactone + H2O | hydrolysis: 67.1 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | dihydrocoumarin + H2O | hydrolysis: 12.99 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | epsilon-caprolactone + H2O | hydrolysis: 14.8 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | gamma-butyrolactone + H2O | hydrolysis: 3.21 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | gamma-decalactone + H2O | hydrolysis: 17.38 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | gamma-heptalactone + H2O | hydrolysis: 5.72 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | gamma-hexalactone + H2O | hydrolysis: 5.17 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | gamma-nonalactone + H2O | hydrolysis: 14.47 micromol/min/mg | Homo sapiens | 4-hydroxynonanoate | - |
? | |
| 3.1.1.17 | gamma-octalactone + H2O | hydrolysis: 6.92 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | gamma-undecalactone + H2O | hydrolysis: 12.72 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | gamma-valerolactone + H2O | hydrolysis: 4.5 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | homogenestic acid lactone + H2O | hydrolysis: 32.95 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | additional information | relating lactones rate of hydrolysis reveal an inverse correlation with the docking energy of the ligands-PON1 complex, and a direct correlation with the lactone side chain length | Homo sapiens | ? | - |
? | |
| 3.1.1.17 | phenyl acetate + H2O | hydrolysis: 112 micromol/min/mg | Homo sapiens | ? | - |
? | |
| 3.1.1.25 | (1R,5S)-oxabicyclooctenone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.1.25 | (1S,5R)-oxabicyclooctenone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.1.25 | 1,3-benzoxazol-2-one + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.1.25 | alpha-angelica lactone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.1.25 | beta-hydroxybutyrolactone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.1.25 | delta-decanolactone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.1.25 | delta-dodecanolactone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.1.25 | delta-hexalactone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.1.25 | delta-nonalactone + H2O | - |
Homo sapiens | 5-hydroxynonanoate | - |
? | |
| 3.1.1.25 | delta-undecatiolactone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.1.25 | delta-valerolactone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.1.25 | dihydrocoumarin + H2O | - |
Homo sapiens | 3-(2-hydroxyphenyl)propanoic acid | - |
? | |
| 3.1.1.25 | epsilon-caprolactone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.1.25 | gamma -nonalactone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.1.25 | gamma-butyrolactone + H2O | - |
Homo sapiens | 4-hydroxybutanoic acid | - |
? | |
| 3.1.1.25 | gamma-decanolactone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.1.25 | gamma-heptalactone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.1.25 | gamma-hexalactone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.1.25 | gamma-octalactone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.1.25 | gamma-undecanolactone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.1.25 | gamma-valerolactone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.1.25 | homogenestic acid lactone + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.17 | paraoxonase1 | - |
Homo sapiens |
| 3.1.1.17 | PON1 | - |
Homo sapiens |
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