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Literature summary extracted from

  • Decker, M.; Kraus, B.; Heilmann, J.
    Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties (2008), Bioorg. Med. Chem., 16, 4252-4261.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.8 5-(1,2-dithiolan-3-yl)-N-[8-(6,7,8,9,10,11-hexahydro-13H-azocino[2,1-b]quinazolin-13-ylideneamino)-octyl]pentanamide
-
 Mus musculus
3.1.1.8 5-ethoxy-3,4-dihydro-2H-pyrrole
-
 Mus musculus
3.1.1.8 6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
 Mus musculus
3.1.1.8 galanthamine
-
 Mus musculus
3.1.1.8 additional information design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties exhibiting competitive and reversible inhibition, overview Mus musculus
3.1.1.8 N-(3-([6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]amino)propyl)-5-(1,2-dithiolan-3-yl)pentanamide
-
 Mus musculus
3.1.1.8 N-(6,7,8,9,10,11-hexahydro-13H-azocino[2,1-b]quinazolin-13-ylidene)octane-1,8-diamine
-
 Mus musculus
3.1.1.8 N-(8-([6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]amino)octyl)-5-(1,2-dithiolan-3-yl)-pentanamide
-
 Mus musculus
3.1.1.8 N-[6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]-1-butanamine
-
 Mus musculus
3.1.1.8 N-[6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]hexane-1,6-diamine
-
 Mus musculus
3.1.1.8 N-[6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]octane-1,8-diamine
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.8 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.8 brain
-
 Mus musculus
-
3.1.1.8 microglia
-
 Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
3.1.1.8 BChE
-
 Mus musculus
3.1.1.8 butyrylcholinesterase
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.8 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.8 7.4
-
 assay at Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.8 0.0023
-
-
 Mus musculus N-[6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]-1-butanamine