Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Naganuma, M.; Nishida, M.; Kuramochi, K.; Sugawara, F.; Yoshida, H.; Mizushina, Y.
    1-deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae (2008), Bioorg. Med. Chem., 16, 2939-2944.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.7 1-deoxyrubralactone potent inhibitor of isozymes pol kappa, pol lambda, pol iota, and pol eta, but does not inhibit DNA polymerase isozymes pol delta, pol epsilon, and pol gamma Homo sapiens
2.7.7.7 1-deoxyrubralactone potent inhibitor Rattus norvegicus
2.7.7.7 additional information not inhibited by 1-deoxyrubralactone and talaroflavone Bos taurus
2.7.7.7 additional information not inhibited by 1-deoxyrubralactone and talaroflavone Brassica oleracea
2.7.7.7 additional information not inhibited by 1-deoxyrubralactone and talaroflavone Escherichia coli
2.7.7.7 additional information not inhibited by 1-deoxyrubralactone and talaroflavone Tequatrovirus T4
2.7.7.7 additional information not inhibited by 1-deoxyrubralactone and talaroflavone Thermus aquaticus
2.7.7.7 talaroflavone
-
 Homo sapiens
2.7.7.7 talaroflavone
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.7 Bos taurus
-
-
-
2.7.7.7 Brassica oleracea
-
-
-
2.7.7.7 Escherichia coli
-
-
-
2.7.7.7 Homo sapiens
-
-
-
2.7.7.7 Rattus norvegicus
-
-
-
2.7.7.7 Tequatrovirus T4
-
-
-
2.7.7.7 Thermus aquaticus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Thermus aquaticus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Escherichia coli diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Homo sapiens diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Rattus norvegicus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Bos taurus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Tequatrovirus T4 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Brassica oleracea diphosphate + DNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.7 DNA polymerase
-
 Thermus aquaticus
2.7.7.7 DNA polymerase
-
 Homo sapiens
2.7.7.7 DNA polymerase
-
 Tequatrovirus T4
2.7.7.7 DNA polymerase alpha
-
 Bos taurus
2.7.7.7 DNA polymerase alpha
-
 Brassica oleracea
2.7.7.7 DNA polymerase beta
-
 Rattus norvegicus
2.7.7.7 DNA polymerase beta
-
 Brassica oleracea
2.7.7.7 DNA polymerase I
-
 Escherichia coli
2.7.7.7 Pol
-
 Thermus aquaticus
2.7.7.7 Pol
-
 Tequatrovirus T4
2.7.7.7 pol alpha
-
 Bos taurus
2.7.7.7 pol alpha
-
 Brassica oleracea
2.7.7.7 pol beta
-
 Rattus norvegicus
2.7.7.7 pol beta
-
 Brassica oleracea
2.7.7.7 pol delta isozyme Homo sapiens
2.7.7.7 POl epsilon isozyme Homo sapiens
2.7.7.7 Pol eta isozyme Homo sapiens
2.7.7.7 Pol gamma isozyme Homo sapiens
2.7.7.7 Pol I
-
 Escherichia coli
2.7.7.7 pol iota isozyme Homo sapiens
2.7.7.7 pol kappa isozyme Homo sapiens
2.7.7.7 Pol lambda isozyme Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.7.7 0.0598
-
 in 50 mM Tris-HCl (pH 7.5) containing 1 mM dithiothreitol, 50% (v/v) glycerol, and 0.1 mM EDTA, at 37°C Homo sapiens 1-deoxyrubralactone