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Literature summary extracted from

  • Xu, X.M.; Carlson, B.A.; Zhang, Y.; Mix, H.; Kryukov, G.V.; Glass, R.S.; Berry, M.J.; Gladyshev, V.N.; Hatfield, D.L.
    New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea (2007), Biol. Trace Elem. Res., 119, 234-241.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.9.1.1 gene secS, DNA and amino acid sequence determination and analysis Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.9.3 additional information mutation of the Sec moiety in SPS2 to Cys results in low enzyme activity of the mutant compared to the wild-type enzyme Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.9.1.1 soluble
-
 Mus musculus
-
-
2.9.1.1 soluble
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.9.3 Mg2+
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.9.1.1 48000
-
 x * 48000, SDS-PAGE Mus musculus
2.9.1.1 48000
-
 x * 48000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.9.3 ATP + selenide Mus musculus SPS2 acts as an autoregulator of selenoprotein synthesis, selenocysteine biosynthesis, overview AMP + selenophosphate + phosphate
-
 ?
2.9.1.1 L-seryl-tRNASec + selenophosphate Mus musculus sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview L-selenocysteinyl-tRNASec + phosphate
-
 ?
2.9.1.1 L-seryl-tRNASec + selenophosphate Homo sapiens sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview L-selenocysteinyl-tRNASec + phosphate
-
 ?
2.9.1.1 additional information Homo sapiens SecS occurs in patients with autoimmune chronic hepatitis as an autoimmune factor that co-precipitated tRNA[Ser]Sec in cell extracts of these individuals andis known as the SLA, soluble liver antigen ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.9.3 Mus musculus P97364
-
-
2.9.1.1 Homo sapiens
-
-
-
2.9.1.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.9.1.1 liver
-
 Mus musculus
-
2.9.1.1 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.9.3 ATP + selenide
-
 Mus musculus AMP + selenophosphate + phosphate
-
 ?
2.7.9.3 ATP + selenide SPS2 acts as an autoregulator of selenoprotein synthesis, selenocysteine biosynthesis, overview Mus musculus AMP + selenophosphate + phosphate
-
 ?
2.9.1.1 L-seryl-tRNASec + selenophosphate
-
 Homo sapiens L-selenocysteinyl-tRNASec + phosphate
-
 ?
2.9.1.1 L-seryl-tRNASec + selenophosphate sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview Mus musculus L-selenocysteinyl-tRNASec + phosphate
-
 ?
2.9.1.1 L-seryl-tRNASec + selenophosphate sps2 encodes a selenoprotein, SPS2, which can serve as selenium donor for the biosynthesis of Sec, as an autoregulator of selenoprotein synthesis, Sec biosynthetic pathway in eukaryotes, overview Homo sapiens L-selenocysteinyl-tRNASec + phosphate
-
 ?
2.9.1.1 L-seryl-tRNASec + selenophosphate the efficiency of tRNA binding in descending order is O-phosphoseryl-tRNA[Ser]Sec, tRNA[Ser]Sec, and seryl-tRNA[Ser]Sec, whereas seryl-tRNASer and tRNASer do not bind at all Mus musculus L-selenocysteinyl-tRNASec + phosphate
-
 ?
2.9.1.1 additional information SecS occurs in patients with autoimmune chronic hepatitis as an autoimmune factor that co-precipitated tRNA[Ser]Sec in cell extracts of these individuals andis known as the SLA, soluble liver antigen Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.9.1.1 ? x * 48000, SDS-PAGE Mus musculus
2.9.1.1 ? x * 48000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.9.3 selenophosphate synthetase 2
-
 Mus musculus
2.7.9.3 Sps2
-
 Mus musculus
2.9.1.1 Sec synthase
-
 Mus musculus
2.9.1.1 Sec synthase
-
 Homo sapiens
2.9.1.1 SecS
-
 Mus musculus
2.9.1.1 SecS
-
 Homo sapiens
2.9.1.1 SLA
-
 Mus musculus
2.9.1.1 SLA
-
 Homo sapiens
2.9.1.1 soluble liver antigen
-
 Mus musculus
2.9.1.1 soluble liver antigen
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.9.3 ATP
-
 Mus musculus
2.9.1.1 pyridoxal 5'-phosphate SecS is a a PLP-dependent transferase Mus musculus
2.9.1.1 pyridoxal 5'-phosphate SecS is a a PLP-dependent transferase Homo sapiens