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Literature summary extracted from

  • Wang, K.; Song, Y.; Chen, D.B.; Zheng, J.
    Protein phosphatase 3 differentially modulates vascular endothelial growth factor- and fibroblast growth factor 2-stimulated cell proliferation and signaling in ovine fetoplacental artery endothelial cells (2008), Biol. Reprod., 79, 704-710.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.16 expressed in fetoplacental artery endothelial cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.16 FK506 selective PPP3 inhibitor Homo sapiens
3.1.3.16 additional information 20 and 40 nM PPP3CA siRNA decreases PPP3CA protein levels by about 97% but not PPP2CA potein expression, knockdown of PPP3CA protein expression enhances vascular endothelial growth factor-beta, but not fibroblast growth factor 2-stimulated cell proliferation, knockdown of PPP3CA protein expression does not significantly affect vascular endothelial growth factor-induced mitogen-activated protein kinase 3/1 and phosphoinositide 3-kinase/v-akt murine thymoma viral oncogen homolog 1 phosphorylation, while attenuates fibroblast growth factor 2-induced mitogen-activated protein kinase 3/1 and phosphoinositide 3-kinase/v-akt murine thymoma viral oncogen homolog 1 phosphorylation Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.16 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.16 phosphoprotein + H2O
-
 Homo sapiens protein + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.16 PPP2CA protein phosphatase 2 catalytic subunit alpha Homo sapiens
3.1.3.16 PPP3
-
 Homo sapiens
3.1.3.16 PPP3CA protein phosphatase 3 catalytic subunit alpha Homo sapiens
3.1.3.16 protein phosphatase 2
-
 Homo sapiens
3.1.3.16 protein phosphatase 3
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
3.1.3.16 Calmodulin
-
 Homo sapiens