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Literature summary extracted from

  • Grkovich, A.; Armando, A.; Quehenberger, O.; Dennis, E.A.
    TLR-4 mediated group IVA phospholipase A2 activation is phosphatidic acid phosphohydrolase 1 and protein kinase C dependent (2009), Biochim. Biophys. Acta, 1791, 975-982.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.4 ATP cellular GIVA PLA2 activity is induced by the treatment of cells with Ca+2 mobilizing agonists, such as the purinergic P2X7 receptor agonist ATP Mus musculus
3.1.1.4 diacylglycerol exogenous diacylglycerol stimulates GIVA PLA2-mediated arachidonic acid release Mus musculus
3.1.1.4 additional information involvement of phosphatidic acid phosphohydrolase 1 (PAP-1) and protein kinase C (PKC) in the Toll-like receptor-4 (TLR-4) activation of GIVA PLA2. Ca+2 influx is not required for TLR-4 mediated activation of the GIVA PLA2 Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.4 additional information PAP-1 inhibition leads to the loss of cyclooxygenase 2 expression and PGE2 release Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 additional information neither PAP-1 nor PKC inhibition reduces GIVA PLA2 synergistic activation by stimulation with Kdo2-Lipid A and ATP. Neither EDTA nor EGTA reduce the arachidonic acid release Mus musculus
3.1.1.4 pyrrophenone pretreatment of cells with pyrrophenone reduces Kdo2-lipid A stimulated arachidonic acid release to background levels Mus musculus
3.1.3.4 bromoenol lactone
-
Mus musculus
3.1.3.4 additional information PAP-1 chemical inhibition does not reduce the synergistic activation of group IVA phospholipase A2 Mus musculus
3.1.3.4 propranolol
-
Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.4 a 3-sn-phosphatidate + H2O Mus musculus
-
a 1,2-diacyl-sn-glycerol + phosphate
-
?
3.1.3.4 additional information Mus musculus phosphatidic acid phosphohydrolase 1 and protein kinase C are required for Toll-like receptor-4-mediated group IVA phospholipase A2 activation, regulation, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Mus musculus
-
-
-
3.1.3.4 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 macrophage
-
Mus musculus
-
3.1.1.4 RAW-264.7 cell
-
Mus musculus
-
3.1.3.4 macrophage
-
Mus musculus
-
3.1.3.4 RAW-264.7 cell
-
Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 glycerophospholipid + H2O
-
Mus musculus arachidonic acid + ?
-
?
3.1.3.4 a 3-sn-phosphatidate + H2O
-
Mus musculus a 1,2-diacyl-sn-glycerol + phosphate
-
?
3.1.3.4 additional information phosphatidic acid phosphohydrolase 1 and protein kinase C are required for Toll-like receptor-4-mediated group IVA phospholipase A2 activation, regulation, overview Mus musculus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.4 GIVA PLA2
-
Mus musculus
3.1.1.4 group IVA phospholipase A2
-
Mus musculus
3.1.3.4 PAP-1
-
Mus musculus
3.1.3.4 phosphatidic acid phosphohydrolase 1
-
Mus musculus