EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.4 | ATP | cellular GIVA PLA2 activity is induced by the treatment of cells with Ca+2 mobilizing agonists, such as the purinergic P2X7 receptor agonist ATP | Mus musculus | |
3.1.1.4 | diacylglycerol | exogenous diacylglycerol stimulates GIVA PLA2-mediated arachidonic acid release | Mus musculus | |
3.1.1.4 | additional information | involvement of phosphatidic acid phosphohydrolase 1 (PAP-1) and protein kinase C (PKC) in the Toll-like receptor-4 (TLR-4) activation of GIVA PLA2. Ca+2 influx is not required for TLR-4 mediated activation of the GIVA PLA2 | Mus musculus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.3.4 | additional information | PAP-1 inhibition leads to the loss of cyclooxygenase 2 expression and PGE2 release | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.4 | additional information | neither PAP-1 nor PKC inhibition reduces GIVA PLA2 synergistic activation by stimulation with Kdo2-Lipid A and ATP. Neither EDTA nor EGTA reduce the arachidonic acid release | Mus musculus | |
3.1.1.4 | pyrrophenone | pretreatment of cells with pyrrophenone reduces Kdo2-lipid A stimulated arachidonic acid release to background levels | Mus musculus | |
3.1.3.4 | bromoenol lactone | - |
Mus musculus | |
3.1.3.4 | additional information | PAP-1 chemical inhibition does not reduce the synergistic activation of group IVA phospholipase A2 | Mus musculus | |
3.1.3.4 | propranolol | - |
Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.3.4 | a 3-sn-phosphatidate + H2O | Mus musculus | - |
a 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
3.1.3.4 | additional information | Mus musculus | phosphatidic acid phosphohydrolase 1 and protein kinase C are required for Toll-like receptor-4-mediated group IVA phospholipase A2 activation, regulation, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.4 | Mus musculus | - |
- |
- |
3.1.3.4 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.1.4 | macrophage | - |
Mus musculus | - |
3.1.1.4 | RAW-264.7 cell | - |
Mus musculus | - |
3.1.3.4 | macrophage | - |
Mus musculus | - |
3.1.3.4 | RAW-264.7 cell | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.4 | glycerophospholipid + H2O | - |
Mus musculus | arachidonic acid + ? | - |
? | |
3.1.3.4 | a 3-sn-phosphatidate + H2O | - |
Mus musculus | a 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
3.1.3.4 | additional information | phosphatidic acid phosphohydrolase 1 and protein kinase C are required for Toll-like receptor-4-mediated group IVA phospholipase A2 activation, regulation, overview | Mus musculus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.1.4 | GIVA PLA2 | - |
Mus musculus |
3.1.1.4 | group IVA phospholipase A2 | - |
Mus musculus |
3.1.3.4 | PAP-1 | - |
Mus musculus |
3.1.3.4 | phosphatidic acid phosphohydrolase 1 | - |
Mus musculus |