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Literature summary extracted from

  • Mourtada-Maarabouni, M.; Williams, G.T.
    Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells (2008), Biochim. Biophys. Acta, 1783, 1490-1502.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.3.16 medicine PP4 regulates both apoptosis and proliferation in human cells and the level of PP4 has a strong influence on gene mutation rate, which is crucial to oncogenesis Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.16 expressed in HEK-293T cells, PP4c over-expressing cells are consistently more sensitive to UV-, cisplatin-, butyrate- and okadaic acid-induced cell death Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.16 cytoplasm some PP4c is cytoplasmic Homo sapiens 5737
-
3.1.3.16 nucleus the subcellular localisation of PP4c is mainly nuclear Homo sapiens 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.16 35000
-
 catalytic subunit PP4c, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.16 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.16 phosphoprotein + H2O
-
 Homo sapiens protein + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.16 Pp4
-
 Homo sapiens
3.1.3.16 PP4c catalytic subunit of protein phosphatase 4 Homo sapiens
3.1.3.16 protein phosphatase 4
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
3.1.3.16 Calmodulin
-
 Homo sapiens