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Literature summary extracted from

  • Theofilopoulos, S.; Lykidis, A.; Leondaritis, G.; Mangoura, D.
    Novel function of the human presqualene diphosphate phosphatase as a type II phosphatidate phosphatase in phosphatidylcholine and triacylglyceride biosynthesis pathways (2008), Biochim. Biophys. Acta, 1781, 731-742.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.4 expression of presqualene diphosphate phosphatase in COS-7 cells, co-expression with CTP:phosphocholine cytidylyltransferase-alpha Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.4 additional information presqualene diphosphate phosphatase, i.e. PA-PSP, overexpression accelerates the synthesis of phosphatidylcholine and causes accumulation of triacylglycerol with concomitant decrease in the rate of phosphatidylinositol synthesis. Co-expression of human CTP:phosphocholine cytidylyltransferase-alpha with PA-PSP enhances the effect of PA-PSP on phosphatidylcholine levels, yet attenuates its effect on triacylglycerol, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.4 additional information the presqualene diphosphate phosphatase is a potent Mg2+-independent, NEM-insensitive type II PAP Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.4 endoplasmic reticulum membrane the enzyme active site exposed to the cytosolic side of the membrane Homo sapiens 5789
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.4 additional information the presqualene diphosphate phosphatase is a potent Mg2+-independent, NEM-insensitive type II PAP Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.4 32400
-
x * 32400, recombinant PA-PSP, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.4 a 3-sn-phosphatidate + H2O Homo sapiens phosphatidate phosphatases are key enzymes in lipid biosynthesis and signaling. Type I PAP enzymes participate in de-novo phospholipid biosynthesis, whereas type II PAP enzymes have an established role in lipid signaling. The eukaryotic, endoplasmic reticulum-resident PA-PSP is a bifunctional enzyme with specific type II PAP activity, and regulates, in addition to type I PAPs, the de-novo biosynthesis of phospholipids and triacylglycerols a 1,2-diacyl-sn-glycerol + phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 a 3-sn-phosphatidate + H2O phosphatidate phosphatases are key enzymes in lipid biosynthesis and signaling. Type I PAP enzymes participate in de-novo phospholipid biosynthesis, whereas type II PAP enzymes have an established role in lipid signaling. The eukaryotic, endoplasmic reticulum-resident PA-PSP is a bifunctional enzyme with specific type II PAP activity, and regulates, in addition to type I PAPs, the de-novo biosynthesis of phospholipids and triacylglycerols Homo sapiens a 1,2-diacyl-sn-glycerol + phosphate
-
?
3.1.3.4 a 3-sn-phosphatidate + H2O the presqualene diphosphate phosphatase is a potent Mg2+-independent, NEM-insensitive type II PAP Homo sapiens a 1,2-diacyl-sn-glycerol + phosphate
-
?

Subunits

EC Number Subunits Comment Organism
3.1.3.4 ? x * 32400, recombinant PA-PSP, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.3.4 PA-PSP
-
Homo sapiens
3.1.3.4 presqualene diphosphate phosphatase
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.4 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.4 6.5
-
assay at Homo sapiens