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Literature summary extracted from

  • Haga, Y.; Hatanaka, K.; Hakomori, S.I.
    Effect of lipid mimetics of GM3 and lyso-GM3 dimer on EGF receptor tyrosine kinase and EGF-induced signal transduction (2008), Biochim. Biophys. Acta, 1780, 393-404.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.1 Epidermal growth factor EGFR dimer is formed by activation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.1 GM3 inhibitory effect on tyrosine phosphorylation of both mono- and dimeric EGFR Homo sapiens
2.7.10.1 lipid mimetic of GM3 inhibitory effect on tyrosine phosphorylation of both mono- and dimeric EGFR Homo sapiens
2.7.10.1 lipid mimetic of lyso-GM3 dimer inhibitory effect on tyrosine phosphorylation of both mono- and dimeric EGFR Homo sapiens
2.7.10.1 lyso-GM3 dimer inhibitory effect on tyrosine phosphorylation of both mono- and dimeric EGFR. A lipid mimetic of lyso-GM3 dimer shows similar strong inhibitory effect on EGF-induced EGFR tyrosine kinase activity, and similar low cytotoxicity, as the authentic lyso-GM3 dimer. Inhibits more strongly than GM3 or a lipid mimetic of GM3 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.10.1 170000
-
 2 * 170000 Homo sapiens
2.7.10.1 340000
-
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.1 A-431 cell
-
 Homo sapiens
-

Subunits

EC Number Subunits Comment Organism
2.7.10.1 dimer 2 * 170000 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.10.1 EGF receptor tyrosine kinase
-
 Homo sapiens
2.7.10.1 Egfr
-
 Homo sapiens
2.7.10.1 epidermal growth factor receptor
-
 Homo sapiens