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Literature summary extracted from

  • Sgobbo, P.; Pacelli, C.; Grattagliano, I.; Villani, G.; Cocco, T.
    Carvedilol inhibits mitochondrial complex I and induces resistance to H2O2 -mediated oxidative insult in H9C2 myocardial cells (2007), Biochim. Biophys. Acta, 1767, 222-232.
    View publication on PubMed

Application

EC Number Application Comment Organism
7.1.1.2 drug development carvedilol exerts its protective antioxidant action both by a direct antioxidant effect and by a preconditioning-like mechanism, via inhibition of mitochondrial complex I Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 carvedilol decreases mitochondrial complex I activity, which is associated with an increase in mitochondrial H2O2 production, total glutathione and protein thiols content Rattus norvegicus
7.1.1.2 rotenone decreases complex I activity by 25%, 27% and 48% in the presence of 0.005, 0.01 and 0.02 mM carvedilol, respectively Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.2 embryo
-
 Rattus norvegicus
-
7.1.1.2 H9c2 cell
-
 Rattus norvegicus
-
7.1.1.2 heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 NADH + decylubiquinone + H+
-
 Rattus norvegicus NAD+ + decylubiquinol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 complex I
-
 Rattus norvegicus
7.1.1.2 NADH-CoQ oxidoreductase
-
 Rattus norvegicus