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Literature summary extracted from

  • Weiner, L.; Shnyrov, V.L.; Konstantinovskii, L.; Roth, E.; Ashani, Y.; Silman, I.
    Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors (2009), Biochemistry, 48, 563-574.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 BW284c51 a reversible elongated gorge-spanning inhibitor, which bridges the two sites, the anionic subsite at the bottom of the active-site gorge and the peripheral anionic site at the entrance to the gorge Tetronarce californica
3.1.1.7 decamethonium a reversible elongated gorge-spanning inhibitor, which bridges the two sites, the anionic subsite at the bottom of the active-site gorge and the peripheral anionic site at the entrance to the gorge Tetronarce californica
3.1.1.7 edrophonium a reversible active-site directed inhibitor, which interacts with the catalytic anionic subsite, at the bottom of the active-site gorge Tetronarce californica
3.1.1.7 propidium a reversible peripheral anionic site inhibitor, which interacts with a site at the entrance to the gorge Tetronarce californica
3.1.1.7 tacrine a reversible active-site directed inhibitor, which interacts with the catalytic anionic subsite, at the bottom of the active-site gorge Tetronarce californica
3.1.1.7 tubocurarine a reversible peripheral anionic site inhibitor, which interacts with a site at the entrance to the gorge Tetronarce californica

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.7 additional information the enzyme is glycosylphosphatidylinositol-anchored Tetronarce californica
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Tetronarce californica
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.7 native enzyme from electric organ by affinity chromatography Tetronarce californica

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.7 electric organ
-
 Tetronarce californica
-

Subunits

EC Number Subunits Comment Organism
3.1.1.7 dimer
-
 Tetronarce californica
3.1.1.7 More interaction between the two subdomains of the enzyme and ligands involved, overview Tetronarce californica

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
 Tetronarce californica

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.7 23
-
 assay at Tetronarce californica

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.7 7
-
 assay at Tetronarce californica

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.7 additional information
-
 additional information inhibition kinetics and thermodynamics, overview Tetronarce californica