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Literature summary extracted from

  • Lei, Z.; Chen, W.; Zhang, M.; Napoli, J.L.
    Reduction of all-trans-retinal in the mouse liver peroxisome fraction by the short-chain dehydrogenase/reductase RRD: induction by the PPAR alpha ligand clofibrate (2003), Biochemistry, 42, 4190-4196.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.300 expression in CHO-K1 cells Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.300 additional information
-
 additional information recombinant RRD reduces free retinal (not bound with cellular retinol binding protein) with a K0.5 value of 0.0023 mM and a Hill constant of 1.7, and reduces CRBP(I)-bound retinal (2fold molar excess of cellular retinol binding protein(I) at each retinal concentration) with a K0.5 value of 0.0086 mM and a Hill constant of 2.1 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.300 peroxisome
-
 Mus musculus 5777
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.300 Mus musculus
-
 male C57BL6J mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.300 brain low mRNA expression Mus musculus
-
1.1.1.300 embryo RRD mRNA expression is initiated on embryo day 7 Mus musculus
-
1.1.1.300 heart high mRNA expression Mus musculus
-
1.1.1.300 kidney high mRNA expression Mus musculus
-
1.1.1.300 liver high mRNA expression Mus musculus
-
1.1.1.300 lung low mRNA expression Mus musculus
-
1.1.1.300 spleen low mRNA expression Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.300 13-cis-retinal + NADPH + H+ 4fold lower activity than with all-trans-retinal Mus musculus 13-cis-retinol + NADP+
-
 ?
1.1.1.300 9-cis-retinal + NADPH + H+ 60fold lower activity than with all-trans-retinal Mus musculus 9-cis-retinol + NADP+
-
 ?
1.1.1.300 all-trans-retinal + NADPH + H+
-
 Mus musculus all-trans-retinol + NADP+
-
 ?
1.1.1.300 additional information recombinant RRD functions with both unbound and CRBP(I) (cellular retinol-binding protein)-bound retinal Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.300 short-chain dehydrogenase/reductase RRD
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.300 NADPH NADPH is at least 30fold more effective than NADH Mus musculus