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Literature summary extracted from

  • Yang, D.; Pearce, R.E.; Wang, X.; Gaedigk, R.; Wan, Y.J.; Yan, B.
    Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin (2009), Biochem. Pharmacol., 77, 238-247.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.1 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.1 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.1 4-nitrophenyl acetate + H2O
-
 Homo sapiens 4-nitrophenol + acetate
-
 ?
3.1.1.1 aspirin + H2O
-
 Homo sapiens acetate + salicylate
-
 ir
3.1.1.1 deltamethrin + H2O
-
 Homo sapiens 3-phenoxybenzaldehyde + (1R,3R)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropanecarboxylate + cyanide
-
 ?
3.1.1.1 oseltamivir + H2O
-
 Homo sapiens ?
-
 ?
3.1.1.1 permethrin + H2O the cis-form of permethrin is favorably hydrolyzed by isozyme HCE2, whereas the trans-form is comparably hydrolyzed by HCE1 and HCE2 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.1 HCE1 isozyme Homo sapiens
3.1.1.1 HCE2 isozyme Homo sapiens