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Literature summary extracted from
- Glycosylphosphatidylinositol-specific phospholipase C regulates transferrin endocytosis in the African trypanosome (2009), Biochem. J., 417, 685-694.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 4.6.1.14 | Q81L | catalytically inactive mutant | Trypanosoma brucei |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.6.1.14 | additional information | GPI-PLC is not detected at endosomes | Trypanosoma brucei | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.6.1.14 | additional information | Trypanosoma brucei | GPI-PLC is a signalling enzyme, and DAG is a second messenger for GPI-PLC. Its enzyme activity is important for stimulating uptake of transferrin | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.6.1.14 | Trypanosoma brucei | - |
427 and RUMP528 | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.6.1.14 | additional information | bloodstream-form Trypanosoma brucei RUMP528 (GPI-PLC-/-) | Trypanosoma brucei | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.6.1.14 | additional information | GPI-PLC is a signalling enzyme, and DAG is a second messenger for GPI-PLC. Its enzyme activity is important for stimulating uptake of transferrin | Trypanosoma brucei | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.6.1.14 | glycosylphosphatidylinositol-specific phospholipase C | - |
Trypanosoma brucei |
| 4.6.1.14 | glycosylphosphatidylinositol-specific phospholipase C | regulates transferrin endocytosis in the African trypanosome, surmise that GPI-PLC regulates transferrin endocytosis in Trypanosoma brucei | Trypanosoma brucei |
| 4.6.1.14 | GPI-PLC | - |
Trypanosoma brucei |
| 4.6.1.14 | GPI-PLC enzyme | - |
Trypanosoma brucei |
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Release 2023.1 (January 2023)
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