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Literature summary extracted from

  • Molle, V.; Reynolds, R.C.; Alderwick, L.J.; Besra, G.S.; Cozzone, A.J.; Fuetterer, K.; Kremer, L.
    EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR (2008), Biochem. J., 410, 309-317.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.11.1 molecular biology EmbR2 is a regulator of PknH activation, thus directly participating in the control of the PknH/EmbR pair Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.1 EmbR2 EmbR2, a homologue of EmbR, inhibits PknH by binding to at least two of the three threonine sites known to undergo autophosphorylation in PknH which leads to a dose-response inhibition of the autokinase activity. Moreover, EmbR2 inhibits PknH-dependent phosphorylation of EmbR in a dose-dependent manner Mycobacterium tuberculosis
2.7.11.1 O6-cyclohexylmethylguanine
-
Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Mycobacterium tuberculosis P9WI71
-
-
2.7.11.1 Mycobacterium tuberculosis H37Rv P9WI71
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.1 phosphoprotein PknH autophosphorylates itsself Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + EmbR PknH phosphorylates the transcriptional regulator EmbR, but not its homologue EmbR2 Mycobacterium tuberculosis ADP + phosphorylated-EmbR
-
?
2.7.11.1 ATP + EmbR PknH phosphorylates the transcriptional regulator EmbR, but not its homologue EmbR2 Mycobacterium tuberculosis H37Rv ADP + phosphorylated-EmbR
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 mycobacterial serine/threonine protein kinase
-
Mycobacterium tuberculosis
2.7.11.1 PknH
-
Mycobacterium tuberculosis
2.7.11.1 serine-threonine kinase
-
Mycobacterium tuberculosis
2.7.11.1 StpK
-
Mycobacterium tuberculosis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.1 37
-
assay at Mycobacterium tuberculosis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.1 7
-
assay at Mycobacterium tuberculosis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.1 0.0011
-
-
Mycobacterium tuberculosis EmbR2
2.7.11.1 0.005
-
-
Mycobacterium tuberculosis O6-cyclohexylmethylguanine