EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.8.27 | gene SMS1 | Mus musculus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.7.8.27 | additional information | S49AR cells show a defect in the synthesis of sphingomyelin and downregulated SMS1, phenotype, overview. Resistance to ALP can be mimicked by small interfering RNA-induced SMS1 suppression, resulting in sphingomyelin deficiency and blockage of raft-dependent internalization of ALP and induction of apoptosis, overview | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.8.27 | additional information | disturbance of cholesterol homoeostasis by 3-beta-[2-(diethylamino)-ethoxy]androst-5-en-17-one, i.e. U18666A, indirectly inhibits sphingomyelin biosynthesis, overview | Mus musculus | |
2.7.8.27 | tricyclodecan-9-yl-xanthogenate | i.e. D609 | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.8.27 | Golgi membrane | SMS1 | Mus musculus | 139 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.8.27 | additional information | Mus musculus | SMS1 is located in the Golgi apparatus, where its two enzymatic products, sphingomyelin and diacylglycerol, play an important role in new lipid raft formation and secretory vesicle formation at the trans-Golgi network for transport to the plasma membrane, sphingomyelin synthesis through SMS1 depends on cholesterol homeostasis. S49AR cells are unable to synthesize sphingomyelin due to downregulated SMS1 expression | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.8.27 | Mus musculus | - |
isozyme SMS1 | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.8.27 | additional information | no expression of SMS1 and SMS2 in alkyl-lysophospholipid-resistant S49AR mouse lymphoma cells | Mus musculus | - |
2.7.8.27 | S49 cell | lymphoma cell line, expression of SMS1, not of SMS2 | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.8.27 | additional information | SMS1 is located in the Golgi apparatus, where its two enzymatic products, sphingomyelin and diacylglycerol, play an important role in new lipid raft formation and secretory vesicle formation at the trans-Golgi network for transport to the plasma membrane, sphingomyelin synthesis through SMS1 depends on cholesterol homeostasis. S49AR cells are unable to synthesize sphingomyelin due to downregulated SMS1 expression | Mus musculus | ? | - |
? | |
2.7.8.27 | N-lauroyl-D-erythro-sphingosylphosphorylcholine + N-(6-[(7-nitro-benz-2-oxa-1,3-diazo-4-yl)amino]caproyl)-ceramide | i.e. lauroyl sphingomyelin and C6-NBD-ceramide | Mus musculus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.8.27 | SM synthase 1 | - |
Mus musculus |
2.7.8.27 | SMS1 | - |
Mus musculus |
2.7.8.27 | sphingomyelin synthase 1 | - |
Mus musculus |