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Literature summary extracted from

  • Goodwin, B.L.; Corbin, K.D.; Pendleton, L.C.; Levy, M.M.; Solomonson, L.P.; Eichler, D.C.
    Troglitazone up-regulates vascular endothelial argininosuccinate synthase (2008), Biochem. Biophys. Res. Commun., 370, 254-258.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.3.4.5 additional information troglitazone, a PPARgamma ligand, and thiazolidinedione up-regulate vascular endothelial argininosuccinate synthase expression, quantitative real time RT-PCR, overview Bos taurus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.4.5 expression analysis, the AS gene promoter contains a a near consensus PPARgamma response element, PPRE, overview Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.5 additional information 1-D-ribofuranosylbenzimidazole suppresses enzyme expression Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.4.5 Mg2+
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.4.5 ATP + L-citrulline + L-aspartate Bos taurus the caveolar-localized endothelial argininosuccinate synthase catalyzes the rate-limiting step of the citrulline-NO cycle, involving not only the regulation of endothelial nitric oxide synthase, but also regulation of cycle, overview AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.5 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.5 aorta
-
 Bos taurus
-
6.3.4.5 endothelial cell aortic Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.5 ATP + L-citrulline + L-aspartate
-
 Bos taurus AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?
6.3.4.5 ATP + L-citrulline + L-aspartate the caveolar-localized endothelial argininosuccinate synthase catalyzes the rate-limiting step of the citrulline-NO cycle, involving not only the regulation of endothelial nitric oxide synthase, but also regulation of cycle, overview Bos taurus AMP + diphosphate + 2-(Nomega-L-arginino)succinate
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.4.5 ATP
-
 Bos taurus