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Literature summary extracted from

  • Parihar, M.S.; Parihar, A.; Villamena, F.A.; Vaccaro, P.S.; Ghafourifar, P.
    Inactivation of mitochondrial respiratory chain complex I leads mitochondrial nitric oxide synthase to become pro-oxidative (2008), Biochem. Biophys. Res. Commun., 367, 761-767.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.1.1.2 malate
-
 Homo sapiens
7.1.1.2 malate when RCC-I is activated, mitochondrial superoxide is decreased by mitochondrial nitric oxide synthase stimulation, whereas decreased superoxide is prevented when mitochondrial nitric oxide synthase is inhibited. RCC-I activation increases mitochondrial S-nitrosoglutathione that is further increased by mitochondrial nitric oxide synthase stimulation and prevented when mitochondrial nitric oxide synthase is inhibited Rattus norvegicus
7.1.1.2 pyruvate
-
 Homo sapiens
7.1.1.2 pyruvate when RCC-I is activated, mitochondrial superoxide is decreased by mitochondrial nitric oxide synthase stimulation, whereas decreased superoxide is prevented when mitochondrial nitric oxide synthase is inhibited. RCC-I activation increases mitochondrial S-nitrosoglutathione that is further increased by mitochondrial nitric oxide synthase stimulation and prevented when mitochondrial nitric oxide synthase is inhibited Rattus norvegicus

Application

EC Number Application Comment Organism
7.1.1.2 additional information crucial role for mitochondrial nitric oxide synthase in oxidative stress caused by mitochondrial complex I inactivation Homo sapiens
7.1.1.2 additional information crucial role for mitochondrial nitric oxide synthase in oxidative stress caused by mitochondrial complex I inactivation Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 rotenone RCC-I inactivation causes a dramatic decrease in mitochondrial NO that is not affected by Mn (III) porphyrin 5,10,15,20-tetrakis(benzoic acid) porphyrin. RCC-I inactivation drastically increases mitochondrial reactive oxygen species, which is prevented when mitochondrial nitric oxide synthase is inhibited or cells are treated with Mn (III) porphyrin 5,10,15,20-tetrakis(benzoic acid) porphyrin. Inactivation of RCC-I in SHSY cells dramatically increases tyrosine nitration of mitochondrial proteins that is fully prevented when mitochondrial nitric oxide synthase is inactivated. RCC-I inactivation leads cytochrome c to diffuse into the cytoplasm indicating its release from the mitochondria Homo sapiens
7.1.1.2 rotenone when RCC-I is inactivated, mitochondrial nitric oxide synthase stimulation dramatically augments the superoxide signal, whereas augmented superoxide signal is prevented when mitochondrial nitric oxide synthase is inhibited and abolished by superoxide dismutase. RCC-I inactivation dramatically increases S-nitrosoglutathione decomposition that is prevented when mitochondrial nitric oxide synthase is inhibited. RCC-I inactivation increases tyrosine-nitrated mitochondrial proteins, causes cytochrome c release and aggregation of mitochondria Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Homo sapiens
-
-
-
7.1.1.2 Rattus norvegicus
-
 Sprague–Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.2 additional information SHSY cell Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 RCC-I
-
 Homo sapiens
7.1.1.2 RCC-I
-
 Rattus norvegicus
7.1.1.2 respiratory chain complex I
-
 Homo sapiens
7.1.1.2 respiratory chain complex I
-
 Rattus norvegicus