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Literature summary extracted from

  • Van Overloop, H.; Van Veldhoven, P.P.
    Ceramide-dependent release of ceramide kinase from cultured cells (2007), Biochem. Biophys. Res. Commun., 364, 169-174.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.138 additional information CERK can respond to stimuli by changing its localization, e.g. from Golgi to plasma membrane upon osmotic swelling, explaining perhaps the conflicting subcellular findings Cricetulus griseus
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2.7.1.138 plasma membrane CHO cell Cricetulus griseus 5886
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.138 ceramide + ATP Cricetulus griseus CERK and its product Cer-1-P are implicated in signaling processes, Cer-1-P stimulates DNA synthesis ceramide 1-phosphate + ADP
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.138 Cricetulus griseus
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.138 CHO cell
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 Cricetulus griseus
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.138 additional information
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 the specific CERK activity in cells exposed for 16-18 h to 0.005 mM C6-ceramide dropped to 18.7% Cricetulus griseus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.138 ceramide + ATP
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 Cricetulus griseus ceramide 1-phosphate + ADP
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 ?
2.7.1.138 ceramide + ATP CERK and its product Cer-1-P are implicated in signaling processes, Cer-1-P stimulates DNA synthesis Cricetulus griseus ceramide 1-phosphate + ADP
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 ?
2.7.1.138 D-erythro-N-hexanoyl-sphingenine + ATP D-erythro isomer of C6-ceramide, the specific CERK activity in cells exposed for 16-18 h to 0.005 mM C6-ceramide dropped to 18.7% Cricetulus griseus D-erythro-N-hexanoyl-sphingenine 1-phosphate + ADP
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 ?
2.7.1.138 D-threo-C6-ceramide + ATP no or only weakly decrease of the specific CERK activity Cricetulus griseus D-threo-C6-ceramide 1-phosphate + ADP
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 ?
2.7.1.138 L-erythro-C6-ceramide + ATP no or only weakly decrease of the specific CERK activity Cricetulus griseus L-erythro-C6-ceramide 1-phosphate + ADP
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 ?
2.7.1.138 L-threo-C6-ceramide + ATP no or only weakly decrease of the specific CERK activity Cricetulus griseus L-threo-C6-ceramide 1-phosphate + ADP
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 ?
2.7.1.138 N-hexanoyl-sphinganine + ATP C6-dihydroceramide Cricetulus griseus N-hexanoyl-sphinganine 1-phosphate + ADP
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 ?
2.7.1.138 N-octyl-sphingenine + ATP C8-ceramine, no or only weakly decrease of the specific CERK activity Cricetulus griseus N-octyl-sphingenine 1-phosphate + ADP
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.138 CERK
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 Cricetulus griseus