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Literature summary extracted from

  • Separovic, D.; Hanada, K.; Maitah, M.Y.; Nagy, B.; Hang, I.; Tainsky, M.A.; Kraniak, J.M.; Bielawski, J.
    Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage (2007), Biochem. Biophys. Res. Commun., 358, 196-202.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.27 stable overexpression of SMS1 in Jurkat cells leading to a 3.8fold increase in SMS activity Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.8.27 additional information overexpression of SMS1 in Jurkat cells leads to suppression of the production of dihydroceramides and dihydrosphingosine, and ceramide Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.27 additional information photosensitizer Pc 4, PDT, induces inhibition of SMS in Jurkat cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.27 Golgi membrane isozyme SMS1 Homo sapiens 139
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.27 additional information Homo sapiens SMS1 suppresses ceramide production and apoptosis post-photodamage ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.27 Homo sapiens
-
 isozyme SMS1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.27 JURKAT cell clone E6-1 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.27 additional information SMS1 suppresses ceramide production and apoptosis post-photodamage Homo sapiens ?
-
 ?
2.7.8.27 phosphatidylcholine + C6-ceramide
-
 Homo sapiens ?
-
 ?
2.7.8.27 phosphatidylcholine + C6-NBD-ceramide i.e. N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine, the fluorogenic derivative of C6-ceramide Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.27 SMS1
-
 Homo sapiens
2.7.8.27 sphingomyelin synthase 1
-
 Homo sapiens