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Literature summary extracted from

  • Choi, J.Y.; Seo, C.S.; Zheng, M.S.; Lee, C.S.; Son, J.K.
    Topoisomerase I and II inhibitory constituents from the bark of Tilia amurensis (2008), Arch. Pharm. Res., 31, 1413-1418.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.2 (-)-epicatechin 98% inhibition at 0.1 mM Homo sapiens
5.6.2.2 (9S,12S,13S)-trihydroxy-(10E)-octadecenoic acid 97% inhibition at 0.1 mM Homo sapiens
5.6.2.2 6-methoxy-7,8-methylenedioxycoumarin 57% inhibition at 0.1 mM Homo sapiens
5.6.2.2 etoposide 78% inhibition at 0.1 mM Homo sapiens
5.6.2.2 lyoniside 12% inhibition at 0.1 mM Homo sapiens
5.6.2.2 nudiposide 9% inhibition at 0.1 mM Homo sapiens
5.6.2.2 scopoletin 16% inhibition at 0.1 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.2 supercoiled pBR 322 plasmid DNA + ATP + H2O
-
 Homo sapiens relaxed pBR 322 plasmid DNA + ADP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.2.2 Topoisomerase II
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
5.6.2.2 ATP
-
 Homo sapiens