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Literature summary extracted from

  • Lannergard, J.; von Eiff, C.; Sander, G.; Cordes, T.; Seggewiss, J.; Peters, G.; Proctor, R.A.; Becker, K.; Hughes, D.
    Identification of the genetic basis for clinical menadione-auxotrophic small-colony variant isolates of Staphylococcus aureus (2008), Antimicrob. Agents Chemother., 52, 4017-4022.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
4.1.3.36 medicine mutations in the menB gene, the gene encoding naphthoate synthase, cause the small-colony variant phenotype, small-colony variants are associated with persistent infections and may be selectively enriched during antibody therapy Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.3.36 o-succinylbenzoyl-CoA Staphylococcus aureus
-
 1,4-dihydroxy-2-naphthoyl-CoA + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.36 Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.36 o-succinylbenzoyl-CoA
-
 Staphylococcus aureus 1,4-dihydroxy-2-naphthoyl-CoA + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.3.36 naphthoate synthase
-
 Staphylococcus aureus