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Literature summary extracted from

  • Graf, C.; Rovina, P.; Bornancin, F.
    A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides (2008), Anal. Biochem., 384(1), 166-169.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.138 stable expression of human CerK in COS-1 cell, named COS-CerK cell, and RBL-2H3 cell Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.138 NVP-231 diamino-benzothiazole derivative, potent inhibitor, no inhibition with its analog NVP-995 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.138 ceramide + ATP Homo sapiens involvement in inflammatory processes and cell growth ceramide 1-phosphate + ADP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.138 Homo sapiens Q8TCT0
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.138 C2-ceramide + ATP C2-Cer is a potent inducer of cell death in CerK-expressing cells Homo sapiens C2-ceramide 1-phosphate + ADP
-
 ?
2.7.1.138 ceramide + ATP
-
 Homo sapiens ceramide 1-phosphate + ADP
-
 ?
2.7.1.138 ceramide + ATP involvement in inflammatory processes and cell growth Homo sapiens ceramide 1-phosphate + ADP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.138 CERK
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.138 0.000012
-
-
 Homo sapiens NVP-231