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Literature summary extracted from

  • Sun, L.; Stenken, J.A.; Yang, A.Y.; Zhao, J.J.; Musson, D.G.
    An in vitro microdialysis methodology to study 11beta-hydroxysteroid dehydrogenase type 1 enzyme activity in liver microsomes (2007), Anal. Biochem., 370, 26-37.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.146 analysis use of microdialysis sampling coupled with liquid chromatography/electrospray ionization mass spectrometry to study 11beta-hydroxysteroid dehydrogenase type 1 catalyzed conversion of stable-isotope-labeled cortisone to cortisol in liver microsome. Results show species-specific reaction profiles, with a five times higher coversion rate in dog than in human and monkey liver microsome Homo sapiens
1.1.1.146 analysis use of microdialysis sampling coupled with liquid chromatography/electrospray ionization mass spectrometry to study 11beta-hydroxysteroid dehydrogenase type 1 catalyzed conversion of stable-isotope-labeled cortisone to cortisol in liver microsome. Results show species-specific reaction profiles, with a five times higher coversion rate in dog than in human and monkey liver microsome Canis lupus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.146 microsome
-
 Homo sapiens
-
-
1.1.1.146 microsome
-
 Canis lupus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Canis lupus
-
-
-
1.1.1.146 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 liver species-specific reaction profiles of 11beta-hydroxysteroid dehydrogenase, with a five times higher conversion rate in dog than in human and monkey liver microsome Homo sapiens
-
1.1.1.146 liver species-specific reaction profiles of 11beta-hydroxysteroid dehydrogenase, with a five times higher conversion rate in dog than in human and monkey liver microsome Canis lupus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 cortisone + NADPH + H+
-
 Homo sapiens cortisol + NADP+
-
 ?
1.1.1.146 cortisone + NADPH + H+
-
 Canis lupus cortisol + NADP+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.146 NADP+
-
 Homo sapiens
1.1.1.146 NADP+
-
 Canis lupus
1.1.1.146 NADPH
-
 Homo sapiens
1.1.1.146 NADPH
-
 Canis lupus