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Literature summary extracted from

  • Zmijewski, J.W.; Lorne, E.; Zhao, X.; Tsuruta, Y.; Sha, Y.; Liu, G.; Siegal, G.P.; Abraham, E.
    Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury (2008), Am. J. Respir. Crit. Care Med., 178, 168-179.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
7.1.1.2 medicine mitochondrial complex I plays an important role in modulating Toll-like receptor 4-mediated neutrophil activation. Metformin, as well as other agents that inhibit mitochondrial complex I, may be useful in the prevention or treatment of acute inflammatory processes in which activated neutrophils play a major role, such as acute lung injury Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 metformin inhibits complex I activity, associated with LPS-induced neutrophil activation. Metformin prevents LPS-induced acute lung injury Mus musculus
7.1.1.2 rotenone inhibits complex I, which is associated with increased ROS generation, LPS-induced nuclear translocation of NF-kappaB and cytokine production in neutrophils. Rotenone pretreatment attenuates LPS-induced acute lung injury Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrion
-
 Mus musculus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Mus musculus
-
 male C57BL/6 mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.2 bone marrow
-
 Mus musculus
-
7.1.1.2 liver
-
 Mus musculus
-
7.1.1.2 lung
-
 Mus musculus
-
7.1.1.2 neutrophil
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 NADH + coenzyme Q1 + H+
-
 Mus musculus NAD+ + reduced coenzyme Q1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 complex I
-
 Mus musculus