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Literature summary extracted from
- Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells (2008), Am. J. Respir. Cell Mol. Biol., 39, 289-295.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.2.1.35 | interleukin 1-beta | acts synergistically with TNF-alpha to increase gene expression and activity | Homo sapiens | |
| 3.2.1.35 | TNF-alpha | acts synergistically with interleukin 1-beta to increase gene expression and activity | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.2.1.35 | expression in human bronchial epithelial cell (HBE) | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.2.1.35 | extracellular | - |
Homo sapiens | - |
- |
| 3.2.1.35 | intracellular | - |
Homo sapiens | 5622 | - |
| 3.2.1.35 | plasma membrane | - |
Homo sapiens | 5886 | - |
| 3.2.1.35 | plasma membrane | also expressed at the apical pole associated with the plasma membrane in bronchial epithelial cells | Homo sapiens | 5886 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.1.35 | additional information | Homo sapiens | Hyal 1 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses | ? | - |
? |  |
| 3.2.1.35 | additional information | Homo sapiens | Hyal 2 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses | ? | - |
? | |
| 3.2.1.35 | additional information | Homo sapiens | Hyal 3 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.2.1.35 | Homo sapiens | O43820 | - |
- |
| 3.2.1.35 | Homo sapiens | O43820 | expression in human bronchial epithelial cell (HBE) | - |
| 3.2.1.35 | Homo sapiens | Q12794 | - |
- |
| 3.2.1.35 | Homo sapiens | Q12794 | expression in human bronchial epithelial cell (HBE) | - |
| 3.2.1.35 | Homo sapiens | Q12891 | - |
- |
| 3.2.1.35 | Homo sapiens | Q12891 | expression in human bronchial epithelial cell (HBE) | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.2.1.35 | bronchial epithelial cell | Hyal-like activity is present in the apical and basolateral secretions from HBE cells where Hyals 1, 2, and 3 are expressed | Homo sapiens | - |
| 3.2.1.35 | bronchoalveolar lavage | increased expression and activity is observed in tracheal sections and in bronchoalveolar lavage (BAL) obtained from subjects with asthma when compared with normal lung donors and healthy volunteers | Homo sapiens | - |
| 3.2.1.35 | tracheobronchial epithelial cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.1.35 | hyaluronan + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.2.1.35 | additional information | Hyal 1 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses | Homo sapiens | ? | - |
? | |
| 3.2.1.35 | additional information | Hyal 2 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses | Homo sapiens | ? | - |
? | |
| 3.2.1.35 | additional information | Hyal 3 is expressed in airway epithelium and may operate in a coordinated fashion to depolymerize hyaluronan during inflammation associated with up-regulation of TNF-alpha and IL-1beta, such as allergen-induced asmatic responses | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.2.1.35 | Hyal 1 | - |
Homo sapiens |
| 3.2.1.35 | HYAL1 | - |
Homo sapiens |
| 3.2.1.35 | Hyal2 | - |
Homo sapiens |
| 3.2.1.35 | HYAL3 | - |
Homo sapiens |
| 3.2.1.35 | hyaluronidase | - |
Homo sapiens |
| 3.2.1.35 | hyaluronidase 2 | - |
Homo sapiens |
| 3.2.1.35 | hyaluronidase 3 | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.2.1.35 | 37 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.2.1.35 | 4.2 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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