EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.4.1.5 | additional information | Rattus norvegicus | study of the pathophysiological role of glyaylase I as an methylglyxal detoxifier in rat ischemia-reperfusion (I/R) injury | ? | - |
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EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.4.1.5 | Rattus norvegicus | - |
- |
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EC Number | Source Tissue | Comment | Organism | Textmining |
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EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.4.1.5 | glutathione + methylglyoxal | methylglyoxal is a highly reactive carbonyl compound generated by carbohydrate oxidation and glycolysis, is a major precursor of protein glycation and induces cytotoxicitay leading to apoptosis | Rattus norvegicus | S-((R)-lactoyl)glutathione | - |
? | |
4.4.1.5 | additional information | study of the pathophysiological role of glyaylase I as an methylglyxal detoxifier in rat ischemia-reperfusion (I/R) injury | Rattus norvegicus | ? | - |
? | |
4.4.1.5 | additional information | knockdown of glyoxalase I by SiRNA transfecetion in rat tubulart cells exacerbates cell-death by hyposia-reoxygenation compared to control cells. Glyoxalase I exerts renoprotective effects in renal ischemia-reperfusion (I/R) injury via the reduction in methylglyoxal accumulation in tubluar cells | Rattus norvegicus | ? | - |
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