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Literature summary extracted from

  • Zhou, Z.; Pyriochou, A.; Kotanidou, A.; Dalkas, G.; van Eickels, M.; Spyroulias, G.; Roussos, C.; Papapetropoulos, A.
    Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress (2008), Am. J. Physiol. Heart Circ. Physiol., 295, H1763-H1771.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.2 3-morpholinosydnonimine i.e. SIN-1 Mus musculus
4.6.1.2 BAY 41-2272
-
Mus musculus
4.6.1.2 H2O2 activates the enzyme, and reduces the cGMP formation activation by nitroprusside and BAY 41-2272 in smooth muscle cells, but enhances the response to HMR-1766, the activation by reactive oxigen species is heme-dependent Mus musculus
4.6.1.2 HMR-1766 stimulates the enzyme, especially heme-free sGC, identification of the interaction region and binding structure of the enzyme by computational modelling Mus musculus
4.6.1.2 menadione
-
Mus musculus
4.6.1.2 nitroprusside
-
Mus musculus
4.6.1.2 rotenone
-
Mus musculus
4.6.1.2 [1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one potentiates the activating effect of HMR-1766 on the wild-type enzyme Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.2 expression of the heme-free alpha1-subunit/H105F beta1-subunit sGC mutant in COS-7 cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
4.6.1.2 H105F the enzyme of heme-free alpha1-subunit/H105F beta1-subunit sGC mutant is not activated by sodium nitroprusside, but by HMR-1766, 1H-[1,2,4]oxidazolol[4,3a]quinoxalin-1-one does not potentiate the activating effect of HMR-1766 in mutant cells, while it does in wild-type cells, binding structure of H105F mutant with HMR-1766, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.2 [1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one inhibits the enzyme and the enzyme activating effect of sodium nitroprusside Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.2 GTP Mus musculus
-
3',5'-cyclic GMP + diphosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.2 smooth muscle cell
-
Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.2 GTP
-
Mus musculus 3',5'-cyclic GMP + diphosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.2 sGC
-
Mus musculus
4.6.1.2 soluble guanylyl cyclase
-
Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
4.6.1.2 heme
-
Mus musculus