EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.2 | 3-morpholinosydnonimine | i.e. SIN-1 | Mus musculus | |
4.6.1.2 | BAY 41-2272 | - |
Mus musculus | |
4.6.1.2 | H2O2 | activates the enzyme, and reduces the cGMP formation activation by nitroprusside and BAY 41-2272 in smooth muscle cells, but enhances the response to HMR-1766, the activation by reactive oxigen species is heme-dependent | Mus musculus | |
4.6.1.2 | HMR-1766 | stimulates the enzyme, especially heme-free sGC, identification of the interaction region and binding structure of the enzyme by computational modelling | Mus musculus | |
4.6.1.2 | menadione | - |
Mus musculus | |
4.6.1.2 | nitroprusside | - |
Mus musculus | |
4.6.1.2 | rotenone | - |
Mus musculus | |
4.6.1.2 | [1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one | potentiates the activating effect of HMR-1766 on the wild-type enzyme | Mus musculus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
4.6.1.2 | expression of the heme-free alpha1-subunit/H105F beta1-subunit sGC mutant in COS-7 cells | Mus musculus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
4.6.1.2 | H105F | the enzyme of heme-free alpha1-subunit/H105F beta1-subunit sGC mutant is not activated by sodium nitroprusside, but by HMR-1766, 1H-[1,2,4]oxidazolol[4,3a]quinoxalin-1-one does not potentiate the activating effect of HMR-1766 in mutant cells, while it does in wild-type cells, binding structure of H105F mutant with HMR-1766, overview | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.2 | [1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one | inhibits the enzyme and the enzyme activating effect of sodium nitroprusside | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.6.1.2 | GTP | Mus musculus | - |
3',5'-cyclic GMP + diphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.6.1.2 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.6.1.2 | smooth muscle cell | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.6.1.2 | GTP | - |
Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.6.1.2 | sGC | - |
Mus musculus |
4.6.1.2 | soluble guanylyl cyclase | - |
Mus musculus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.2 | heme | - |
Mus musculus |