Literature summary extracted from
Guo, D.; Nguyen, T.; Ogbi, M.; Tawfik, H.; Ma, G.; Yu, Q.; Caldwell, R.W.; Johnson, J.A.
Protein kinase C-epsilon coimmunoprecipitates with cytochrome oxidase subunit IV and is associated with improved cytochrome-c oxidase activity and cardioprotection (2007), Am. J. Physiol. Heart Circ. Physiol., 293, H2219-H2230.
Activating Compound
EC Number |
Activating Compound |
Comment |
Organism |
Structure |
---|
7.1.1.9 |
additional information |
ischemic preconditioning administered before prolonged ischemia-reperfusion induces a 1.9fold increase in coimmunoprecipitation of cytochrome oxidase subunit IV, with anti-PKC-epsilon antisera and a 2fold enhancement of cytochrome-c oxidase activity. Intact mitochondria show virtually no cytochrome-c oxidase activity, unless they are permeablized with n-dodecyl-beta,D-maltoside |
Rattus norvegicus |
|
Application
EC Number |
Application |
Comment |
Organism |
---|
7.1.1.9 |
medicine |
recovery of enhanced cytochrome-c oxidase activity may play a role in ischemic preconditioning protection |
Rattus norvegicus |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
7.1.1.9 |
KCN |
1 mM completely inhibits |
Rattus norvegicus |
|
Localization
EC Number |
Localization |
Comment |
Organism |
GeneOntology No. |
Textmining |
---|
7.1.1.9 |
mitochondrion |
- |
Rattus norvegicus |
5739 |
- |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
7.1.1.9 |
Rattus norvegicus |
- |
Sprague-Dawley rats |
- |
Source Tissue
EC Number |
Source Tissue |
Comment |
Organism |
Textmining |
---|
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
7.1.1.9 |
ferrocytochrome c + O2 + H+ |
- |
Rattus norvegicus |
ferricytochrome c + H2O |
- |
? |
|