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Literature summary extracted from

  • Li, C.H.; Zhang, Q.; Teng, B.; Mustafa, S.J.; Huang, J.Y.; Yu, H.G.
    Src tyrosine kinase alters gating of hyperpolarization-activated HCN4 pacemaker channel through Tyr531 (2008), Am. J. Physiol. Cell Physiol., 294, C355-C362.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.2 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine PP2, AG-1897 Homo sapiens
2.7.10.2 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine PP2, AG-1897 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.10.2 60000
-
 determined by SDS-PAGE and Western Blot analysis Mus musculus
2.7.10.2 60000
-
 determined by SDS-PAGE and Western Blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + [protein]-L-tyrosine Mus musculus
-
 ADP + [protein]-L-tyrosine phosphate
-
 ?
2.7.10.2 ATP + [protein]-L-tyrosine Homo sapiens
-
 ADP + [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens P12931
-
-
2.7.10.2 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.10.2 protein extracts from cells, transfected with plasmids containing the HCN4 gene, are prepared Mus musculus
2.7.10.2 protein extracts from cells, transfected with plasmids containing the HCN4 gene, are prepared Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.2 HEK-293 cell
-
 Homo sapiens
-
2.7.10.2 HL-1 cell HL-1 cardiomyocyte Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine substrate HCN4, tyrosine 531 is phosphorylated Mus musculus ADP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine phosphate
-
 ?
2.7.10.2 ATP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine substrate HCN4, tyrosine 531 is phosphorylated Homo sapiens ADP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine phosphate
-
 ?
2.7.10.2 ATP + [protein]-L-tyrosine
-
 Mus musculus ADP + [protein]-L-tyrosine phosphate
-
 ?
2.7.10.2 ATP + [protein]-L-tyrosine
-
 Homo sapiens ADP + [protein]-L-tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 Src tyrosine kinase
-
 Mus musculus
2.7.10.2 Src tyrosine kinase
-
 Homo sapiens