Literature summary extracted from

Das, A.K.; Mizuguchi, H.; Kodama, M.; Dev, S.; Umehara, H.; Kitamura, Y.; Matsushita, C.; Takeda, N.; Fukui, H.
Sho-seiryu-to suppresses histamine signaling at the transcriptional level in TDI-sensitized nasal allergy model rats (2008), Allergol. Int., 58, 81-88.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
4.1.1.22	toluene 2,4-diisocyanate	toluene 2,4-diisocyanate provocation shows a significant up-regulation of histidine decarboxylase gene expression in rats, prolonged pre-treatment of Sho-seiryu-to significantly suppresses the mRNA level of HDC upregulated by toluene 2,4-diisocyanate	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.1.1.22	Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.1.1.22	L-histidine	-	Rattus norvegicus	histamine + CO2	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
4.1.1.22	HDC	-	Rattus norvegicus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
4.1.1.22	pyridoxal 5'-phosphate	-	Rattus norvegicus

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Release 2023.1 (January 2023)