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Literature summary extracted from

  • Wagh, P.K.; Peace, B.E.; Waltz, S.E.
    Met-related receptor tyrosine kinase Ron in tumor growth and metastasis (2008), Adv. Cancer Res., 100, 1-33.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.1 12-O-tetradecanoylphorbol-13-acetate upregulates Ron protein expression Mus musculus
2.7.10.1 chicken macrophage stimulating-protein MSP, activates Gallus gallus
2.7.10.1 hepatocyte growth factor-like protein stimulates Homo sapiens

Application

EC Number Application Comment Organism
2.7.10.1 medicine Ron is a critical factor in tumorigenesis Mus musculus
2.7.10.1 medicine Ron is a critical factor in tumorigenesis and its inhibition, alone or in combination with current therapies, may prove beneficial in the treatment of cancer patients Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.10.1 stable expression of wild-type and constitutively active murine Ron mutants in NIH3T3 mouse fibrobalst cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.10.1 D1232V is more active than the wild-type, produces tumors in nude mice and is highly metastatic Mus musculus
2.7.10.1 M1231T equivalent tumor latency and 100% tumor formation as the wild-type Mus musculus
2.7.10.1 M1254T is more active than the wild-type, produces tumors in nude mice and is highly metastatic Mus musculus
2.7.10.1 additional information mouse model with total loss of Ron protein, mice are lethal at an early stage of embryo development, mice hemizygous for the deletion of Ron are viable and fertile, but display an enhanced response to inflammation, are more susceptible to endotoxic shock and display an impaired ability to regulate nitric oxide. Mouse model in which the extracellular and transmembrane domains of Ron are preserved, along with eight amino acids of the intracellular domain, while ablation of the cytoplasmic domain results in complete loss of Ron intracellular signaling, homozygous mice with this germline deletion are viable, fertile and display no gross phenotypic abnormalities, but show an enhanced response to both acute and cell-mediated inflammatory stimuli. Mutant with insertion of beta-galactosidase gene into exon 1 of the mouse Ron gene, so that transcription of the reporter arises from the endogenous reporter and translates from its own start site. Homozygous mice with this mutation are viable and phenotypic normal, but show ablation of activity of Ron Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.1 geldanamycin
-
 Homo sapiens
2.7.10.1 gemcitabine
-
 Homo sapiens
2.7.10.1 humanized monoclonal antibody blocks the interaction of Ron with hepatocyte growth factor-like protein and diminishes Ron phosphorylation and its downstream signaling Homo sapiens
2.7.10.1 humanized monoclonal antibody significantly decreases tumor growth of murine xenografts from subcutaneously injected lung, colon, and pancreatic cancer cell lines in nude mice Mus musculus
2.7.10.1 mouse monoclonal blocking antibody increases apoptosis by 32% as compared to gemcitabine alone Homo sapiens
2.7.10.1 siRNA significantly reduces cancer cell proliferation, motility, and increases apoptotic susceptibility of colorectal carcinoma cells Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.10.1 35000
-
 1 * 150000 + 1 * 35000 Homo sapiens
2.7.10.1 150000
-
 1 * 150000 + 1 * 35000 Homo sapiens
2.7.10.1 185000
-
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.1 Bos taurus
-
-
-
2.7.10.1 Canis lupus
-
-
-
2.7.10.1 Equus caballus
-
-
-
2.7.10.1 Gallus gallus
-
-
-
2.7.10.1 Homo sapiens
-
-
-
2.7.10.1 Macaca mulatta
-
-
-
2.7.10.1 Mus musculus
-
-
-
2.7.10.1 Rattus norvegicus
-
-
-
2.7.10.1 Strongylocentrotus purpuratus
-
-
-
2.7.10.1 Takifugu rubripes
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.1 adrenal gland
-
 Mus musculus
-
2.7.10.1 bone ossification centers of developing bone Mus musculus
-
2.7.10.1 breast cancer cell
-
 Mus musculus
-
2.7.10.1 breast cancer cell overexpression of Ron Homo sapiens
-
2.7.10.1 BxPC-3 cell Ron is highly expressed Homo sapiens
-
2.7.10.1 central nervous system
-
 Mus musculus
-
2.7.10.1 CFPAC-1 cell Ron is highly expressed Homo sapiens
-
2.7.10.1 colon
-
 Mus musculus
-
2.7.10.1 colon
-
 Homo sapiens
-
2.7.10.1 colonic cancer cell
-
 Mus musculus
-
2.7.10.1 colonic cancer cell
-
 Homo sapiens
-
2.7.10.1 DU-145 cell Ron is highly expressed Homo sapiens
-
2.7.10.1 embryo expression during the process of implantation and placentation Mus musculus
-
2.7.10.1 epididymis
-
 Mus musculus
-
2.7.10.1 epithelium
-
 Mus musculus
-
2.7.10.1 esophagus
-
 Homo sapiens
-
2.7.10.1 gastric cancer cell
-
 Mus musculus
-
2.7.10.1 gastrointestinal tract
-
 Mus musculus
-
2.7.10.1 hematopoietic stem cell
-
 Mus musculus
-
2.7.10.1 hepatocyte
-
 Homo sapiens
-
2.7.10.1 keratinocyte foreskin Homo sapiens
-
2.7.10.1 kidney
-
 Mus musculus
-
2.7.10.1 kidney cancer cell
-
 Mus musculus
-
2.7.10.1 Kupffer cell
-
 Homo sapiens
-
2.7.10.1 L3.6pl cell Ron is highly expressed Homo sapiens
-
2.7.10.1 liver
-
 Homo sapiens
-
2.7.10.1 liver epression of Ron from day 12.5 Mus musculus
-
2.7.10.1 liver cancer cell
-
 Mus musculus
-
2.7.10.1 liver cancer cell
-
 Homo sapiens
-
2.7.10.1 LNCaP cell Ron is highly expressed Homo sapiens
-
2.7.10.1 lung
-
 Homo sapiens
-
2.7.10.1 lung cancer cell
-
 Mus musculus
-
2.7.10.1 lung cancer cell
-
 Homo sapiens
-
2.7.10.1 macrophage Ron is expressed on alveolar and peritoneal and monocyte-derived macrophages Homo sapiens
-
2.7.10.1 additional information present in ductal breast carcinoma cells, epithelial tumor cells, stomach cancer cells, NSCLC cell line and SCLC cell line. Ron is highly expressed in FG cells. Ron is not expressed on circulating human monocytes and is absent from gall bladder Homo sapiens
-
2.7.10.1 additional information present in hematopoietic cancer cells. Ron is highly expressed in 4964-PDA cells, 4964-LM cells, 5143-PDA cells and 5143-LM cells Mus musculus
-
2.7.10.1 ovary
-
 Mus musculus
-
2.7.10.1 ovary cancer cell Ron and Met are significantly coexpressed. Also another short form Ron is present Homo sapiens
-
2.7.10.1 pancreas Ron is highly expressed in fetal pancreas as compared to adults. Also another short form Ron is present Homo sapiens
-
2.7.10.1 pancreatic cancer cell
-
 Mus musculus
-
2.7.10.1 pancreatic cancer cell
-
 Homo sapiens
-
2.7.10.1 PC-3 cell Ron is highly expressed Homo sapiens
-
2.7.10.1 peripheral nervous system
-
 Mus musculus
-
2.7.10.1 placenta
-
 Mus musculus
-
2.7.10.1 prostate cancer cell
-
 Homo sapiens
-
2.7.10.1 small intestine
-
 Homo sapiens
-
2.7.10.1 stomach
-
 Mus musculus
-
2.7.10.1 stomach Ron is highly expressed in fetal stomach as compared to adults Homo sapiens
-
2.7.10.1 T-47D cell Ron is highly expressed Homo sapiens
-
2.7.10.1 testis
-
 Mus musculus
-
2.7.10.1 uterus
-
 Mus musculus
-
2.7.10.1 ZR-75-1 cell Ron is highly expressed Homo sapiens
-

Subunits

EC Number Subunits Comment Organism
2.7.10.1 heterodimer 1 * 150000 + 1 * 35000 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.10.1 macrophage stimulating 1-receptor
-
 Homo sapiens
2.7.10.1 MST1R
-
 Homo sapiens
2.7.10.1 Ron
-
 Mus musculus
2.7.10.1 Ron
-
 Homo sapiens
2.7.10.1 Ron
-
 Rattus norvegicus
2.7.10.1 Ron
-
 Bos taurus
2.7.10.1 Ron
-
 Equus caballus
2.7.10.1 Ron
-
 Macaca mulatta
2.7.10.1 Ron
-
 Canis lupus
2.7.10.1 Ron
-
 Strongylocentrotus purpuratus
2.7.10.1 Ron
-
 Takifugu rubripes
2.7.10.1 RON receptor tyrosine kinase
-
 Mus musculus
2.7.10.1 RON receptor tyrosine kinase
-
 Homo sapiens
2.7.10.1 RON receptor tyrosine kinase
-
 Rattus norvegicus
2.7.10.1 RON receptor tyrosine kinase
-
 Bos taurus
2.7.10.1 RON receptor tyrosine kinase
-
 Equus caballus
2.7.10.1 RON receptor tyrosine kinase
-
 Macaca mulatta
2.7.10.1 RON receptor tyrosine kinase
-
 Canis lupus
2.7.10.1 RON receptor tyrosine kinase
-
 Strongylocentrotus purpuratus
2.7.10.1 RON receptor tyrosine kinase
-
 Takifugu rubripes
2.7.10.1 sea receptor
-
 Gallus gallus
2.7.10.1 stem cell derived tyrosine kinase
-
 Mus musculus
2.7.10.1 STK
-
 Mus musculus