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Literature summary extracted from
- Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase from Streptococcus suis serotype 2 (2008), Acta Crystallogr. Sect. F, 64, 997-999.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 4.1.2.14 | medicine | 2-keto-3-deoxy-6-phosphogluconate aldolase is an attractive target for drug therapy in the case of human Streptococcus suis infections | Streptococcus suis |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.1.2.14 | into the vector pET21a for expression in Escherichia coli BL21DE3 cells | Streptococcus suis |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 4.1.2.14 | the structure of 2-keto-3-deoxy-6-phosphogluconate aldolase is solved at a resolution of 2.8 A | Streptococcus suis |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.1.2.14 | 22920 | - |
calculated | Streptococcus suis |
| 4.1.2.14 | 23000 | - |
determined by SDS-PAGE | Streptococcus suis |
| 4.1.2.14 | 60000 | - |
determined by gel filtration, trimer | Streptococcus suis |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.2.14 | 2-dehydro-3-deoxy-D-gluconate 6-phosphate | Streptococcus suis | - |
pyruvate + D-glyceraldehyde 3-phosphate | - |
r |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.2.14 | Streptococcus suis | A4VVI7 | serotype 2 | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.1.2.14 | using a nickel-affinity and a Superdex 200 column | Streptococcus suis |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.2.14 | 2-dehydro-3-deoxy-D-gluconate 6-phosphate | - |
Streptococcus suis | pyruvate + D-glyceraldehyde 3-phosphate | - |
r | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.1.2.14 | homotrimer | - |
Streptococcus suis |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.2.14 | 2-keto-3-deoxy-6-phosphogluconate aldolase | - |
Streptococcus suis |
| 4.1.2.14 | KDPG aldolase | - |
Streptococcus suis |
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