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Literature summary extracted from

  • Xie, P.; Williams, D.S.; Atilla-Gokcumen, G.E.; Milk, L.; Xiao, M.; Smalley, K.S.; Herlyn, M.; Meggers, E.; Marmorstein, R.
    Structure-based design of an Organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity (2008), ACS Chem. Biol., 3, 305-316.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.1.137 medicine PI3K lipid kinase is an attractive target for the development of therapeutic agents to treat cancer and other related diseases Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.137 expressed in Escherichia coli Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.1.137 in complex with inhibitor E5E2, hanging drop vapour diffusion method, 100 mM Tris pH 7.2, 200 mM ammonium sulfate, 21% PEG 4000 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.137 Ead125
-
 Homo sapiens
2.7.1.137 Ly-294002
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.137 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.137
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidylinositol
-
 Homo sapiens ADP + phosphatidylinositol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.137 phosphatidyl-inositol-3-kinase
-
 Homo sapiens
2.7.1.137 PI3Kgamma p110gamma catalytic subunit Homo sapiens