EC Number | Application | Comment | Organism |
---|---|---|---|
1.6.5.2 | medicine | acute manganese intoxication, similarly to that of cadmium and other heavy metals, increases both the hepatic level of Nrf2 and its transfer from the cytoplasm to the nucleus where it actively regulates the induction of phase II enzymes, e.g. NQO1 | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.6.5.2 | cytosol | - |
Rattus norvegicus | 5829 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.6.5.2 | Cd2+ | strongly stimulates NQO1 in the liver of intoxicated rats | Rattus norvegicus | |
1.6.5.2 | Mn2+ | strongly stimulates NQO1 in the liver of intoxicated rats | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.6.5.2 | Rattus norvegicus | - |
male Wistar rats | - |
1.6.5.2 | Rattus norvegicus | - |
male, Wistar | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.6.5.2 | liver | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.6.5.2 | 0.00022 | - |
48 h after after oral administration of vitamin E | Rattus norvegicus |
1.6.5.2 | 0.00023 | - |
control, 24 h | Rattus norvegicus |
1.6.5.2 | 0.00024 | - |
24 h after after oral administration of vitamin E | Rattus norvegicus |
1.6.5.2 | 0.00024 | - |
48 h after oral administration of manganese | Rattus norvegicus |
1.6.5.2 | 0.00024 | - |
control, 24 h | Rattus norvegicus |
1.6.5.2 | 0.00025 | - |
48 h after oral administration of cadmium and vitamin E | Rattus norvegicus |
1.6.5.2 | 0.00026 | - |
48 h after after oral administration of cadmium | Rattus norvegicus |
1.6.5.2 | 0.00055 | - |
24 h after oral administration of manganese | Rattus norvegicus |
1.6.5.2 | 0.00056 | - |
24 h after oral administration of cadmium and vitamin E | Rattus norvegicus |
1.6.5.2 | 0.00059 | - |
24 h after after oral administration of cadmium | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.6.5.2 | menadione + NADH | - |
Rattus norvegicus | reduced menadione + NAD+ | - |
? | |
1.6.5.2 | NADPH + H+ + quinone | TNF alpha and LPS induce Nqo1 mRNA expression | Rattus norvegicus | NADP+ + ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.6.5.2 | NAD(P)H:quinone reductase | - |
Rattus norvegicus |
1.6.5.2 | NADPH:quinone oxidoreductase 1 | - |
Rattus norvegicus |
1.6.5.2 | NQO1 | - |
Rattus norvegicus |