Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Casalino, E.; Calzaretti, G.; Landriscina, M.; Sblano, C.; Fabiano, A.; Landriscina, C.
    The Nrf2 transcription factor contributes to the induction of alpha-class GST isoenzymes in liver of acute cadmium or manganese intoxicated rats: comparison with the toxic effect on NAD(P)H:quinone reductase (2007), Toxicology, 237, 24-34.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.6.5.2 medicine acute manganese intoxication, similarly to that of cadmium and other heavy metals, increases both the hepatic level of Nrf2 and its transfer from the cytoplasm to the nucleus where it actively regulates the induction of phase II enzymes, e.g. NQO1 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.5.2 cytosol
-
Rattus norvegicus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.6.5.2 Cd2+ strongly stimulates NQO1 in the liver of intoxicated rats Rattus norvegicus
1.6.5.2 Mn2+ strongly stimulates NQO1 in the liver of intoxicated rats Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.2 Rattus norvegicus
-
male Wistar rats
-
1.6.5.2 Rattus norvegicus
-
male, Wistar
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.2 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.6.5.2 0.00022
-
48 h after after oral administration of vitamin E Rattus norvegicus
1.6.5.2 0.00023
-
control, 24 h Rattus norvegicus
1.6.5.2 0.00024
-
24 h after after oral administration of vitamin E Rattus norvegicus
1.6.5.2 0.00024
-
48 h after oral administration of manganese Rattus norvegicus
1.6.5.2 0.00024
-
control, 24 h Rattus norvegicus
1.6.5.2 0.00025
-
48 h after oral administration of cadmium and vitamin E Rattus norvegicus
1.6.5.2 0.00026
-
48 h after after oral administration of cadmium Rattus norvegicus
1.6.5.2 0.00055
-
24 h after oral administration of manganese Rattus norvegicus
1.6.5.2 0.00056
-
24 h after oral administration of cadmium and vitamin E Rattus norvegicus
1.6.5.2 0.00059
-
24 h after after oral administration of cadmium Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.2 menadione + NADH
-
Rattus norvegicus reduced menadione + NAD+
-
?
1.6.5.2 NADPH + H+ + quinone TNF alpha and LPS induce Nqo1 mRNA expression Rattus norvegicus NADP+ + ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.6.5.2 NAD(P)H:quinone reductase
-
Rattus norvegicus
1.6.5.2 NADPH:quinone oxidoreductase 1
-
Rattus norvegicus
1.6.5.2 NQO1
-
Rattus norvegicus