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Literature summary extracted from

  • Lalaouni, A.; Henderson, C.; Kupper, C.; Grant, M.H.
    The interaction of chromium (VI) with macrophages: depletion of glutathione and inhibition of glutathione reductase (2007), Toxicology, 236, 76-81.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 Cr6+ during the metabolism of Cr VI, glutathione reductase activity is inhibited Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.7 additional information Homo sapiens prior inhibition of glutathione reductase activity protects against the toxicity of Cr6+ to a significant extent, suggesting that it reduces Cr6+ to a toxic metabolite ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Homo sapiens
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 macrophage
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 Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 additional information prior inhibition of glutathione reductase activity protects against the toxicity of Cr6+ to a significant extent, suggesting that it reduces Cr6+ to a toxic metabolite Homo sapiens ?
-
 ?