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Literature summary extracted from

  • Wallace, L.J.
    A small dopamine permeability of storage vesicle membranes and end product inhibition of tyrosine hydroxylase are sufficient to explain changes occurring in dopamine synthesis and storage after inhibition of neuron firing (2007), Synapse, 61, 715-723.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.16.2 dopamine end product inhibition Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.16.2 cytosol
-
Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2 Rattus norvegicus key enzyme in dopamine biosynthesis, the majority of dopamine is derived from recycling after dopamine exocytosis, but loss in dopamine leads to de novo synthesis of dopamine, due to increased enzyme activity since the feedback enzyme inhibition by dopamine is reduced, regulation, overview 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.16.2 brain
-
Rattus norvegicus
-
1.14.16.2 corpus striatum
-
Rattus norvegicus
-
1.14.16.2 neuron dopaminergic neurons Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.16.2 additional information
-
-
Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2
-
Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
?
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2 key enzyme in dopamine biosynthesis, the majority of dopamine is derived from recycling after dopamine exocytosis, but loss in dopamine leads to de novo synthesis of dopamine, due to increased enzyme activity since the feedback enzyme inhibition by dopamine is reduced, regulation, overview Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.16.2 tyrosine hydroxylase
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.16.2 tetrahydrobiopterin
-
Rattus norvegicus