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Literature summary extracted from
- Peroxisomes and beta-oxidation of long-chain unsaturated carboxylic acids (1991), Scand. J. Clin. Lab. Invest. Suppl., 204, 33-46.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.124 | Clofibrate | - |
Rattus norvegicus |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.124 | pent-4-enoate | inhibitory effect alleviated by clofibrate | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.35 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
| 1.3.1.124 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
| 1.3.1.124 | peroxisome | - |
Rattus norvegicus | 5777 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.124 | 2-cis,4-cis/trans-dienoyl-CoA + NADPH + H+ | Rattus norvegicus | - |
3-trans-enoyl-CoA + NADP+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.35 | Rattus norvegicus | - |
- |
- |
| 1.3.1.124 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.3.1.124 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.35 | liver | - |
Rattus norvegicus | - |
| 1.3.1.124 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.35 | 2.77 | - |
trans-3-decenoyl-CoA as a substrate | Rattus norvegicus |
| 1.3.1.124 | 0.0124 | - |
trans-2-trans-4-hexedienoyl-CoA as a substrate | Rattus norvegicus |
| 1.3.1.124 | 0.0331 | - |
trans-2-trans-4-hexedienoyl-CoA as a substrate, clofibrate-treated | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.124 | (2E,4E)-hexa-2,4-dienoyl-CoA + NADPH + H+ | - |
Rattus norvegicus | (3E)-hex-3-enoyl-CoA + NADP+ | - |
? | |
| 1.3.1.124 | 2-cis,4-cis/trans-dienoyl-CoA + NADPH + H+ | - |
Rattus norvegicus | 3-trans-enoyl-CoA + NADP+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.35 | 3-hydroxyacyl-CoA dehydrogenase | - |
Rattus norvegicus |
| 1.3.1.124 | 2,4-dienoyl-CoA reductase | - |
Rattus norvegicus |
| 4.2.1.119 | 2-enoyl-CoA hydratase 2 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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