Literature summary extracted from

Vethe, N.T.; Bremer, S.; Bergan, S.
IMP dehydrogenase basal activity in MOLT-4 human leukaemia cells is altered by mycophenolic acid and 6-thioguanosine (2007), Scand. J. Clin. Lab. Invest., 68, 277-285.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.205	6-thioguanosine	expression of isoform IMPDH2 increases modestly in response to 6-thioguanosine exposure. However, the basal enzyme activity decreases when the cells are exposed to a proliferation-blocking 6-thioguanosine concentration	Homo sapiens
1.1.1.205	Mycophenolic acid	biphasic concentration-dependent influence on inosine 5'-phosphate dehydrogenase basal activity. At concentrations around or below IC50 value, mycophenolic acid increases the basal enzymic activity, associated with elevated expression of isoform IMPDH2. Despite increased expression, the basal enzyme activity decreases following exposure to high mycophenolic acid concentrations	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.205	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.205	MOLT-4 cell	leukemia cell	Homo sapiens	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)