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Literature summary extracted from

  • Smeets, A.; Loumaye, E.; Clippe, A.; Rees, J.F.; Knoops, B.; Declercq, J.P.
    The crystal structure of the C45S mutant of annelid Arenicola marina peroxiredoxin 6 supports its assignment to the mechanistically typical 2-Cys subfamily without any formation of toroid-shaped decamers (2008), Protein Sci., 17, 700-710.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.11.1.24
-
 Arenicola marina

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.11.1.24 mutant C45S is crystallized by hanging drop vapour diffusion method, at 18°C, in 0.1 M Bis-tris pH 5.5, 25% (w/v) PEG3350, 0.001 M dithiothreitol, and 0.02% (w/v) sodium azide Arenicola marina

Protein Variants

EC Number Protein Variants Comment Organism
1.11.1.24 C45S dimeric mutant Arenicola marina

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.24 Arenicola marina Q1AN22
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.11.1.24
-
 Arenicola marina

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.24 H2O2 + reduced thioredoxin
-
 Arenicola marina H2O + oxidized thioredoxin
-
 ?

Subunits

EC Number Subunits Comment Organism
1.11.1.24 homodimer mutant enzyme C45S, X-ray crystallography Arenicola marina

Synonyms

EC Number Synonyms Comment Organism
1.11.1.24 peroxiredoxin 6
-
 Arenicola marina
1.11.1.24 Prdx6 PRDX6 is a typical 2-Cys PRDX that functions more like a cytoprotective antioxidant enzyme or a modulator of peroxide-dependent cell signaling rather than a molecular chaperone Arenicola marina

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.1.24 thioredoxin
-
 Arenicola marina