Literature summary extracted from

Ozbek, Z.; Kucukali, C.I.; Ozkok, E.; Orhan, N.; Aydin, M.; Kilic, G.; Sazci, A.; Kara, I.
Effect of the methylenetetrahydrofolate reductase gene polymorphisms on homocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives (2008), Prog. Neuropsychopharmacol. Biol. Psychiatry, 32, 1331-1337.

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.5.1.20	A222V	the muattion leads to elevated total homocysteine concentration and reduced folate and vitamin B12 levels, but is not associated with the development of bipolar disorders	Homo sapiens
1.5.1.20	E429D	the muattion leads to elevated total homocysteine concentration and reduced folate and vitamin B12 levels, but is not associated with the development of bipolar disorders	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.5.1.20	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.5.1.20	blood	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.5.1.20	5,10-methylenetetrahydrofolate + reduced acceptor	-	Homo sapiens	5-methyltetrahydrofolate + oxidized acceptor	-	ir

Synonyms

EC Number	Synonyms	Comment	Organism
1.5.1.20	methylenetetrahydrofolate reductase	-	Homo sapiens
1.5.1.20	MTHFR	-	Homo sapiens

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Release 2023.1 (January 2023)