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Literature summary extracted from

  • Rascon, A.; Soderling, S.H.; Schaefer, J.B.; Beavo, J.A.
    Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei (2002), Proc. Natl. Acad. Sci. USA, 99, 4714-4719.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.53
-
 Trypanosoma brucei

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.53 3-isobutyl-1-methylxanthine
-
 Trypanosoma brucei
3.1.4.53 dipyridamole
-
 Trypanosoma brucei
3.1.4.53 etazolate
-
 Trypanosoma brucei
3.1.4.53 papaverine
-
 Trypanosoma brucei

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.53 0.0024
-
 adenosine 3',5'-cyclic phosphate
-
 Trypanosoma brucei

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.53 Trypanosoma brucei Q9GQU6
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.53 adenosine 3',5'-cyclic phosphate + H2O
-
 Trypanosoma brucei adenosine 5'-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.53 TbPDE2B
-
 Trypanosoma brucei

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.53 0.027
-
-
 Trypanosoma brucei dipyridamole
3.1.4.53 0.127
-
-
 Trypanosoma brucei papaverine
3.1.4.53 0.127
-
-
 Trypanosoma brucei etazolate
3.1.4.53 0.304
-
-
 Trypanosoma brucei 3-isobutyl-1-methylxanthine