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Literature summary extracted from

  • Maeda, A.; Maeda, T.; Sun, W.; Zhang, H.; Baehr, W.; Palczewski, K.
    Redundant and unique roles of retinol dehydrogenases in the mouse retina (2007), Proc. Natl. Acad. Sci. USA, 104, 19565-19570.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.105 all-trans-retinal + NAD(P)H + H+ Mus musculus RDH5 has only a minor in vivo all-trans RDH activity all-trans-retinol + NAD(P)+
-
 ?
1.1.1.300 all-trans-retinal + NADPH + H+ Mus musculus RDH12 is dispensable in support of the visual cycle but appears to be a key component in clearance of free all-trans-retinal, thereby preventing accumulation of N-retinylidene-N-retinylethanolamine (a toxic substance known to contribute to retinal degeneration) and photoreceptor cell death all-trans-retinol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.105 Mus musculus O55240
-
-
1.1.1.300 Mus musculus Q8BYK4
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.105 retina
-
 Mus musculus
-
1.1.1.300 retina
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.105 all-trans-retinal + NAD(P)H + H+
-
 Mus musculus all-trans-retinol + NAD(P)+
-
 ?
1.1.1.105 all-trans-retinal + NAD(P)H + H+ RDH5 has only a minor in vivo all-trans RDH activity Mus musculus all-trans-retinol + NAD(P)+
-
 ?
1.1.1.300 all-trans-retinal + NADPH + H+
-
 Mus musculus all-trans-retinol + NADP+
-
 ?
1.1.1.300 all-trans-retinal + NADPH + H+ RDH12 is dispensable in support of the visual cycle but appears to be a key component in clearance of free all-trans-retinal, thereby preventing accumulation of N-retinylidene-N-retinylethanolamine (a toxic substance known to contribute to retinal degeneration) and photoreceptor cell death Mus musculus all-trans-retinol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.300 RDH12
-
 Mus musculus