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Literature summary extracted from

  • Yoo, M.H.; Xu, X.M.; Carlson, B.A.; Patterson, A.D.; Gladyshev, V.N.; Hatfield, D.L.
    Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication (2007), PLoS ONE, 2, e1112.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.8.1.9 medicine TR1 acts largely as a pro-cancer protein and it is a primary target in cancer therapy Mus musculus
1.8.1.9 medicine TR1 acts largely as a pro-cancer protein and it is a primary target in cancer therapy Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.8.1.9 selenium selenoprotein Mus musculus
1.8.1.9 selenium selenoprotein Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Homo sapiens Q16881
-
-
1.8.1.9 Mus musculus Q9JMH6
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.9 A-549 cell human lung non-small cell carcinoma Homo sapiens
-
1.8.1.9 ACHN cell human kidney renal cell carcinoma Homo sapiens
-
1.8.1.9 HCT-116 cell human colon cell adenocarcinoma Homo sapiens
-
1.8.1.9 LLC1 cell
-
 Mus musculus
-
1.8.1.9 NIH-3T3 cell TR1 is uniquely overexpressed in cancer cells and its knockdown in a mouse cancer cell line driven by oncogenic k-ras results in orphological changes characteristic of parental (normal) cells, without significant effect on cell growth under normal growth conditions. When grown in serum-deficient medium, TR1 deficient cancer cells lose self-sufficiency of growth, manifest a defective progression in their S phase and a decreased expression of DNA polymerase alpha Mus musculus
-
1.8.1.9 SNB-19 cell human cell glioblastoma Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 thioredoxin reductase 1
-
 Mus musculus
1.8.1.9 thioredoxin reductase 1
-
 Homo sapiens
1.8.1.9 TR1
-
 Mus musculus
1.8.1.9 TR1
-
 Homo sapiens